Abstract： Objective： To observe the curative effect of Danhong injection for patients with chronic pulmonary heart disease. Methods：A total of 71 cases of patients with aggravated chronic pulmonary heart disease were selected and divided into the control group and the observation group according to the random number table method. The control group was treated with phentolamine mesylate， and the observation group was additionally treated with Danhong injection based on the treatment of the control group. The levels of blood gas indexes，lung function，inflammatory factors and N- terminal probrain natriuretic peptide (NT- proBNP) as well as adverse reactions in the two groups were compared. Results： After treatment，the levels of partial pressure of oxygen in arterial- blood (PaO2)，forced expiratory volume in one second (FEV1) and the percentage of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) in the two groups were increased when compared with those before treatment(P＜0.05)；the levels of tumor necrosis factor-α (TNF-α)，endothelin-1 (ET- 1)， hypersensitivity C- reaction protein(hs- CRP)， NT- proBNP， brain natriuretic peptide (BNP) and cardiac troponin I (cTnI) in serum as well as carbon dioxide partial pressure(PaCO2) were decreased(P＜0.05). After treatment， the levels of PaO2，FEV1 and FEV1/FVC in the observation group were higher than those in the control group(P＜0.05)，and the levels of TNF- α，hs-CRP，ET-1，NT-proBNP，cTnI and BNP in serum as well as PaCO2 were lower(P＜0.05). During treatment， there was no significant difference being found in the comparison of the incidences of adverse reactions between the two groups(P＞0.05). Conclusion： The therapy of Danhong injection combined with phentolamine mesylate for patients with chronic pulmonary heart disease can effectively relieve their blood gas indexes and lung function， reduce the levels of inflammatory factors，and improve their heart function.