Abstract：Objective：To observe the clinical effect of Rougan Huoxue tang combined with western medicine for hepatitis B cirrhosis complicated with portal hypertension. Methods： A total of 96 cases of patients with hepatitis B cirrhosis complicated with portal hypertension were selected and divided into the control group and the observation group according to the random number table method， 48 cases in each group. The control group was treated with entecavir tablets， bicyclic alcohol tablets and propranolol hydrochloride tablets，and the observation group was additionally treated with Rougan Huoxue tang based on the treatment of the control group. Both groups were treated for eight weeks. The clinical effect in the two groups was compared，and the improvement of liver function，portal vein hemodynamics and Chinese medicine syndromes in the two groups were observed. Results：The total effective rate was 91.67% in the observation group，higher than that of 77.08% in the control group(P＜0.05). After treatment， the portal vein blood flow velocity (SPV) in the two groups was increased when compared with that before treatment， and the main portal vein diameter (DPV) and the portal blood flow (QPV) were decreased (P＜0.05)；the SPV in the observation group was higher than that in the control group，and DPV and QPV in the observation group were lower than those in the control group(P＜0.05). After treatment， the levels of alanine aminotransferase (ALT) and total bilirubin (TBil) in the two groups were decreased when compared with those before treatment (P＜0.05)， and the albumin (Alb) levels in the two groups were increased(P＜0.05)； the levels of ALT and TBil in the observation group were lower than those in the control group(P＜0.05)， and the Alb level was higher(P＜0.05). After treatment， the levels of collagen Ⅳ (C Ⅳ)， hyaluronic acid (HA)， type Ⅲ procollagen (PC Ⅲ) and laminin (LN) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above levels in the observation group were lower than those in the control group(P＜0.05). After treatment，Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the score in the observation group was lower than that in the control group(P＜0.05). Conclusion：The therapy of Rougan Huoxue tang combined with western medicine for hepatitis B cirrhosis complicated with portal hypertension can enhance the clinical effect，and effectively improve the clinical symptoms，liver function and portal vein hemodynamics patients.