Abstract： Objective： To observe the clinical effect of compound Huoxueling tang combined with routine western medicine for preventing deep venous thrombosis(DVT) of lower extremities after surgery for tibial plateau fracture. Methods： A total of 80 cases of patients with tibial plateau fracture were randomly divided into the treatment group and the control group，40 cases in each group. The control group was treated with routine western medicine including anticoagulation，antiinfection and analgesia， and the treatment group was additionally treated with compound Huoxueling tang based on the treatment of the control group. Both groups were treated for two weeks. The levels of coagulation function，hemorheology， inflammatory factors and oxidative stress as well as the incidence of DVT in the two groups were analyzed and compared. Results： No DVT occurred in the treatment group， and three cases(7.50% ) occurred in the control group； there was no significant difference being found in the comparison of the incidence of DVT between the two groups(P＞0.05). Before treatment，there was no significant difference being found in the comparison of the levels of coagulation function including prothrombin time(PT)，activated partial thromboplastin time(APTT)，and thrombin time(TT)，hemorheology including plasma viscosity， whole blood high shear viscosity and fibrinogen(Fib)， inflammatory factors including tumornecrosis factor- alpha (TNF- α)， interleukin- 6(IL- 6) and interleukin- 8(IL- 8)， and oxidative stress including superoxide dismutase(SOD) and malondialdehyde(MDA) between the two groups(P＞0.05). After treatment， PT， APTT and TT in the two groups were increased when compared with those before treatment(P＜0.05)，and PT，APTT and TT in the treatment group were higher than those in the control group(P＜0.05)；the levels of plasma viscosity，whole blood high shear viscosity and FIB in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of the above three indexes in the treatment group were lower than those in the control group(P＜0.05)；the levels of TNF- α，IL- 6 and IL- 8 in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels in the treatment group were lower than those in the control group(P＜0.05)； SOD levels in the two groups were increased when compared with those before treatment(P＜0.05)，and MDA levels were decreased(P＜0.05)；SOD in the treatment group was higher than that in the control group(P＜0.05)， and MDA was lower(P＜0.05). Conclusions： The therapy of compound Huoxueling tang combined with routine treatment has significant curative effect in intervening the formation of DVT after surgery for tibial plateau fracture，which can delay the coagulation time，improve the hemodynamics，and reduce the levels of inflammatory factors and oxidative stress，thus preventing the thrombosis.