Abstract ： In the prevention and treatment of COVID-19 ， Prof. SHEN Zhongyuan summed up a set of treatment methods combining macro syndrome differentiation of Chinese medicine with micro diagnosis and treatment of western medicine. He chose specific Chinese medicine prescriptions to treat COVID- 19，and believed that the early pathogenesis of COVID-19 is the wind-toxin and warm epidemic attacking the exterior，which hurts the offensive qi of the lung. In the middle stage， its pathogenesis is the toxic heat obstructing the lung， resulting in the disturbance of qi movement and spleen deficiency and phlegm coagulation(damp coagulation). In the critical stage，its pathogenesis is the intense pathogenic heat， and the deeper the heat，the severer the reversal coldness，leading to thin fluid consumption and thick fluid desertion，or yin exhaustion in the interior and yang desertion in the exterior. In the convalescence stage， its pathogenesis is the qi- yin depletion and fluid consumption of the lung and stomach. According to the pathogenesis of COVID- 19 in different stages， Qingwen NO.1，NO.2 and NO.3 Mixture were designed to treat patients in the early，middle and convalescent stages，and based on different pathogenesis，Shenmai yin，Angong Niuhuang pills and Zixue pellets were recommended for patients in the critical stage，which achieved good clinical effect.