人参健脾汤加减联合双歧杆菌四联活菌片治疗腹腔镜胆囊切除术后腹泻临床研究
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R256.34

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河南省中医药科学研究专项课题(2018JDZX055)


Clinical Study on Modified Renshen Jianpi Tang Combined with Bifidobacterium Quadruple Viable Tablets for Diarrhea After Laparoscopic Cholecystectomy
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    摘要:

    目的:观察人参健脾汤加减联合双歧杆菌四联活菌片治疗腹腔镜胆囊切除术后腹泻的临床疗效。方法:选取72 例腹腔镜胆囊切除术后腹泻患者,按随机数字表法分为人参健脾汤组与对照组,每组36 例。对照组给予双歧杆菌四联活菌片治疗,人参健脾汤组在对照组基础上加用人参健脾汤加减治疗,2 组均连续治疗4 周。比较2 组临床疗效及复发率,观察2 组治疗前后症状积分,血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α) 水平及球杆比正常率的变化。结果:人参健脾汤组总有效率为94.4%,高于对照组的80.6%(P<0.05)。治疗后,2 组大便性状、大便次数、腹胀腹痛积分均较治疗前降低(P<0.05),人参健脾汤组大便性状、大便次数、腹胀腹痛积分均低于对照组(P<0.05)。治疗后,2 组血清IL-6、TNF-α 水平均较治疗前降低(P<0.05),人参健脾汤组血清IL-6、TNF-α 水平均低于对照组(P<0.05)。治疗后,人参健脾汤组球杆比正常率为97.2%,高于对照组的80.6%(P<0.05)。治疗后随访3 个月,人参健脾汤组复发率为11.8%,低于对照组的34.5%(P<0.05)。结论:人参健脾汤加减联合双歧杆菌四联活菌片治疗腹腔镜胆囊切除术后腹泻,可明显改善患者的临床症状,控制炎症反应,调节肠道菌群,降低复发率。

    Abstract:

    Abstract: Objective: To observe the clinical effect of modified Renshen Jianpi tang combined with bifidobacterium quadruple viable tablets for diarrhea after laparoscopic cholecystectomy. Methods: A total of 72 cases of patients with diarrhea after laparoscopic cholecystectomy were selected and divided into the control group and the Renshen Jianpi Tang group according to the random number table method, 36 cases in each group. The control group was treated with bifidobacterium quadruple viable tablets,and the Renshen Jianpi tang group was additionally treated with modified Renshen Jianpi tang based on the treatment of the control group. Both groups were treated for four weeks. The clinical effect and recurrence rates in the two groups were compared. Before and after treatment,the changes in the symptom scores,the levels of interleukin- 6(IL- 6) and tumor necrosis factor- α(TNF- α) in serum and the normal ratio of proportion of cocci and bacilli in the two groups were observed. Results: The total effective rate was 94.4% in the Renshen Jianpi tang group, higher than that of 80.6% in the control group(P<0.05). After treatment,the scores of the stool traits,fecal frequency and abdominal distension and abdominal pain in the two groups were decreased when compared with those before treatment(P< 0.05), and the above indexes in the Renshen Jianpi tang group were lower than those in the control group(P<0.05). After treatment, the levels of IL- 6 and TNF- α in serum in the two groups were decreased when compared with those before treatment(P<0.05), and the levels in the Renshen Jianpi tang group were lower than those in the control group(P<0.05). After treatment,the normal ratio of proportion of cocci and bacilli was 97.2% in the Renshen Jianpi tang group,higher than that of 80.6% in the control group(P<0.05). After three months of follow-up after treatment,the recurrence rate was 11.8% in the Renshen Jianpi tang group, lower than that of 34.5% in the control group(P<0.05). Conclusion: The therapy of modified Renshen Jianpi tang combined with bifidobacterium quadruple viable tablets for diarrhea after laparoscopic cholecystectomy can significantly improve the clinical symptoms,control the inflammatory responses,regulate the alteration of intestinal flora,and reduce the recurrence rate.

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张兆宏,刘翔,王兆阳,黄晶晶,张楠.人参健脾汤加减联合双歧杆菌四联活菌片治疗腹腔镜胆囊切除术后腹泻临床研究[J].新中医,2021,53(13):36-39

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  • 在线发布日期: 2021-07-11
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