Abstract：Objective：To observe the clinical effect of modified Huanglian Wendan tang for chronic gastritis of spleenstomach dampness-heat type. Methods：A total of 64 cases of patients with chronic gastritis of spleen-stomach dampnessheat type were enrolled so as to conduct prospective study，and were randomly divided into the study group and the control group，32 cases in each group. The control group was given routine western medicine，and the study group was additionally given the oral administration of modified Huanglian Wendan tang based on the treatment of the control group. Both groups were continuously treated for 15 days. After treatment，gastroscopy was performed in both groups，and the curative effect was determined. Results： After treatment， syndrome scores of stomach duct pain， poor appetite and heartburn， pantothenic acid，bitter taste in the mouth and fetid mouth odor，heaviness in the four limbs，sticky stool，lassitude of spirit and lack of strength in the study group were lower than those in the control group(P＜0.05)，and the total score of Chinese medicine syndrome was lower than that in the control group(P＜0.05). After treatment，grading of curative effect according to results from gastroscopy in the study group was significantly better than that in the control group(P＜0.05). Conclusion： Modified Huanglian Wendan tang has a good clinical effect in the treatment of chronic gastritis of spleen-stomach dampnessheat type，which can relieve symptoms of stomach duct pain and repair gastric mucosal injury.