Abstract：Objective：To observe the effect of Wuzi Yanzong tang on the contents of uric acid(UA) and homocysteine(Hcy) in serum in the treatment of patients with mild cognitive im pairment in parkinson disease(PD-MCI) of kidney deficiency and marrow depletion type. Methods：A total of 91 PD- MCI patients of kidney deficiency and marrow depletion type who met inclusion criteria were selected and divided into two groups according to the random number table method. The control group (45 cases) was given donepezil hydrochloride tablets， and the observation(46 cases) was additionally given Wuzi Yanzong tang based on the treatment of the control group. After six-week and twelve-week treatment，the clinical effect，Chinese medicine syndrome score，Mini-Mental State Examination(MMSE)，Montreal Cognitive Assessment(MoCA)，as well as the contents of UA and Hcy in serum were observed in the two groups. Results：The total clinical effective rate was 93.48% in the observation group，significantly higher than that of 71.11% in the control group，the difference being significant(P＜0.05). After six- week and twelve- week treatment，Chinese medicine syndrome scores and the contents of Hcy in serum in the two groups were significantly decreased when compared with those before treatment， with a trend of progressive decrease，and the two indexes above in the observation group were significantly lower than those in the same period in the control group， differences being significant(P＜0.01). After six- week and twelve- week treatment， scores of MMSE and MoCA as well as the content of UA in serum in the two groups were significantly increased when compared with those before treatment，with a trend of progressive increase，and the three indexes above in the observation group were significantly high than those in the same period in the control group，differences being significant(P＜0.01). After treatment，blood routine， the liver function and the kidney function，electrocardiogram，blood pressure，heart rate，and other tests were examined， and no abnormal events occurred in the two groups. Conclusion： For patients with Parkinson disease- mild cognitive impairment of kidney deficiency and marrow depletion type， Wuzi Yanzong tang can significantly enhance clinical effect， relieve their clinical symptoms，and improve cognitive impairment and the contents of uric acid and homocysteine in serum， with safety.