Abstract： Objective： To observe the clinical effect of Sihe yin for hepatitis B complicated with liver cirrhosis ascites. Methods：A total of 81 cases of patients with hepatitis B complicated with liver cirrhosis ascites were randomly divided into two groups. The control group was given routine comprehensive treatment of western medicine，and the treatment group was additionally treated with Sihe yin based on the treatment scheme of the control group. Changes in symptoms，signs，the liver function，and indexes of liver fibrosis before and after treatment were observed and compared between the two groups. Results：The total clinical effective rate was 95.1% in the treatment group，and 82.5% in the control group，the difference being significant(P＜0.05). After treatment， levels of alanine aminotransferase(ALT)， aspartate aminotransferase(AST)， albumin(ALB)， and total bilirubin(TBil) in the two groups were improved when compared with those before treatment(P＜ 0.05)，and the improvement of ALT，AST and Alb in the treatment group was better than that in the control group(P＜0.05). Hyaluronidase(HA)， type Ⅲ procollagen(PC Ⅲ)， type Ⅳ collagen( Ⅳ C)， laminin(LN)， and liver stiffness measure(LSM) detected by FibroScan in the treatment group were improved when compared with those before treatment，differences being significant(P＜0.05). After treatment，in the control group，only HA，Ⅳ C，and LSM were improved when compared with those before treatment，differences being significant(P＜0.05). The improvement on HA，PC Ⅲ，Ⅳ C，LN，and LSM in the treatment group was better than that in the control group， differences being significant(P＜0.05). There was no significant adverse reaction in the two groups during the treatment. Conclusion：Sihe yin can effectively relieve the clinical symptoms of patients with hepatitis B complicated with liver cirrhosis ascites，and improve the liver function and indexes of liver fibrosis， with the function of alleviating liver inflammation and fibrosis.