Abstract：Objective：To observe the clinical effect of Tongmai Huoxue prescription combined with alprostadil on patients with arteriosclerosis occlusion of lower limbs. Methods： A total of 102 cases with arteriosclerosis occlusion of lower limbs were divided into two groups according to random number table method. Both groups were given basic treatment. Fifty cases in the control group were additionally given alprostadil for treatment； fifty- two cases in the combination group were additionally treated with modified Tongmai Huoxue tang according to syndrome differentiation based on the treatment of the control group. The clinical effect was observed， and the levels of anklebrachial index(ABI)， superficial femoral artery diameter，peak flow rate，cyclic guanosine monophosphate(cGMP) and cyclic adenosine monophosphate(cAMP) of platelets before and after treatment were evaluated and compared between the two groups. Results： The total effective rate was 92.31% in the combination group， significantly higher than that of 74.00% in the control group， the difference being significant(P＜0.05). After treatment，the levels of ABI，superficial femoral artery diameter，and cAMP of platelet in the two groups were significantly increased when compared with those before treatment， while the above three levels in the combination group were significantly higher than those in the control group，differences being significant(P＜0.05). The levels of peak flow rate of superficial femoral artery and cGMP of platelets in the two groups were significantly decreased when compared with those before treatment，while the above two levels in the combination group were significantly lower than those in the control group， differences being significant(P＜0.05). Conclusion： The therapy of modified Tongmai Huoxue prescription combined with alprostanil for patients with arteriosclerosis occlusion of lower limbs，can significantly improve the limb ischemia，which is better than alprostanil alone.