Abstract： Objective： To observe the clinical effect of Hongtengjian enema liquid combined with levofloxacin and ornidazole for chronic pelvic inflammation. Methods： A total of 90 cases of patients with chronic pelvic inflammation were randomly divided into the control group and the observation group，45 cases in each group. The control group was treated with levofloxacin and ornidazole，and the observation group was additionally treated with retention enema with Hongtengjian enema liquid based on the treatment of the control group. Before and after treatment ， the levels of high-sensitivity C-reactive protein(hs-CRP)，monocyte chemotactic protein 1(MCP-1) and tumor necrosis factor-α(TNF-α) in serum in the two groups were detected. The clinical effect and the incidence of adverse reactions during treatment in the two groups were observed and compared. Results：The total effective rate was 93.33% in the observation group and 77.78% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels ofhs-CRP，MCP-1 and TNF-α between the two groups(P＞0.05)；after treatment，the above indexes in the two groups were decreased when compared with those before treatment(P＜0.05)，and the indexes in the observation group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 6.67% in the observation group and 17.78% in the control group， the difference being significant(P＜0.05). Conclusion： Hongtengjian enema liquid combined with routine antibiotics for chronic pelvic inflammation can improve the curative effect， effectively reduce inflammatory factors in serum，whose curative effect is effective，safe and reliable.