Abstract： Objective： To observe the clinical effect of Fuzheng Jiedu tang combined with methylprednisolone for systemic lupus erythematosus. Methods：A total of 74 cases of patients with systemic lupus erythematosus were selected and divided into the study group and the control group according to random number table method，37 cases in each group. The control group was given methylprednisolone， and the study group was given Fuzheng Jiedu tang combined with methylprednisolone. The clinical effect， scores of Systemic Lupus Erythematosus Disease Activity Index(SLEDAI)， the content of interferon- γ(IFN- γ) in serum， the rate of myelosuppression， and the incidence of adverse reactions were compared between the two groups. Results： The total effective rate was 97.30% in the study group， higher than that of 81.08% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of SLEDAI scores between the two groups(P＞0.05). After four- week and eight- week treatment，SLEDAI scores in the two groups were gradually decreased，and the score in the study group was lower than that in the control group at the same time point， differences being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of IFN-γ contents in serum between the two groups(P＞0.05). After fourweek and eight-week treatment，IFN-γ contents in serum in the two groups were gradually decreased，and the content in the study group was lower than that in the control group at the same time point，differences being significant(P＜0.05). After treatment，the rate of myelosuppression was 10.81% in the study group，which was significantly lower than that of 32.43% in the control group，the difference being significant(P＜0.05). The incidence of adverse reactions was 16.22% in the study group， significantly lower than that of 37.84% in the control group， the difference being significant(P＜0.05). Conclusion： For patients with systemic lupus erythematosus，the therapy of Fuzheng Jiedu tang combined with methylprednisolone can safely improve their clinical symptoms and IFN-γ content in serum，and reduce the rate of myelosuppression.