Abstract： Objective： To observe the effect of Tuling Wendan tang combined with Xingnao Kaiqiao acupuncture method on cerebral blood flow as well as levels of 5-hydroxytryptamine(5-HT)， lysophosphatidic acid(LPA) ， and matrix metalloproteinase-9(MMP-9) in serum in patients with migraine of phlegm turbidity harrasing the upper body type. Methods： A total of 72 cases of patients with migraine of phlegm turbidity harrasing the upper body type were selected and divided into the observation group and the control group according to the random number table method， 36 cases in each group. The control group was given flunarizine hydrochloride， and the observation group was additionally given Tuling Wendan tang combined with Xingnao Kaiqiao acupuncture method based on the treatment of the control group. Both groups were treated for one month. The curative effect was compared between the two groups. Before and after treatment，the improvement of symptoms，cerebral blood flow [anterior cerebral artery(ACA)，intracranial vertebral artery(VA)，middlecerebral artery(MCA)， basilar artery(BA)，and posterior cerebral artery(PCA)] velocity，levels of 5-HT，LPA，and MMP-9 in serum，as well as the incidence of adverse reactions were compared between the two groups. Results：The total effective rate was 94.44% in the observation group，higher than that of 75.00% in the control group(P＜0.05). When compared with those in the same group before treatment，the scores of pain degree，seizure times，and duration of headache，headache index，velocity of ACA， VA， MCA， BA， and PCA， as well as levels of LPA and MMP- 9 in serum in the two groups were decreased after treatment(P＜0.05)，and levels of 5-HT in serum were increased(P＜0.05). When compared with those in the control group after treatment，the scores of pain degree，seizure times，and duration of headache，headache index，velocity of ACA， VA， MCA， BA， and PCA， as well as levels of LPA and MMP- 9 in serum in the observation group were lower after treatment(P＜0.05)，and levels of 5-HT in serum were higher(P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P＞0.05). Conclusion： The therapy of Tuling Wendan tang combined with Xingnao Kaiqiao acupuncture method has significant curative effect on patients with migraine of phlegm turbidity harrasing the upper body type，which can significantly relieve clinical symptoms and improve cerebral blood flow，without increasing adverse reactions. Its mechanism may be closely related to increase in the level of 5-HT in serum and decrease in levels of LPA and MMP-9.