Abstract： Objective： To observe the clinical effect of manipulation release combined with the external application of Wentong ointment for periarthritis humeroscapularis. Methods： A total of 69 cases of patients with periarthritis humeroscapularis were randomly divided into three groups，namely，the manipulation group，the combination group，and the Wentong ointment group. Before treatment as well as after one-week ， two-week ， and four-week treatment ， Constant-Murley Score for evaluating the function of shoulder joint [pain，activities of daily living(ADL)，range of motion(ROM)， and the total score] was determined， and the changes in each score above before and after treatment were compared. Results： After one- week treatment， the total effective rate of clinical effect was 77.27% in the manipulation group， 68.18% in the Wentong ointment group，and 86.36% in the combination group，no significance in the difference among the three groups(P＞0.05). After two-week treatment，the total effective rate of clinical effect was 86.36% in the manipulation group， 77.27% in the Wentong ointment group， and 90.91% in the combination group， no significance in the difference among the three groups(P＞0.05). After four- week treatment， the total effective rate of clinical effect was 90.91% in the manipulation group，90.91% in the Wentong ointment group，and 95.45% in the combination group，the difference being significant among the three groups(P＜0.01). After four- week treatment，the scores of pain，ADL，ROM，as well as the total score of Constant-Murley Score in the combination group were significantly better than those in the manipulation group and the Wentong ointment group(P＜0.05). After four-week treatment，when compared scores of pain，ADL，ROM，and total score between the manipulation group and the Wentong ointment group，there was no significance in differences(P＞ 0.05). No adverse reactions occurred in the three groups. Conclusion：In the treatment of periarthritis humeroscapularis，the therapy of manipulation release combined with the external application of Wentong ointment has a good curative effect， which can relieve pain and increase range of motion. During one- week and two- week treatment， the curative effect of simple external application of Wentong ointment is inferior or comparable to that of manipulation release but comparable to that of manipulation release during four-week treatment.