Abstract：Objective：To observe the rehabilitation effect of Chinese medicine comprehensive continuous nursing based on Wechat platform intervening discharged patients after percutaneous coronary intervention(PCI). Methods： A total of 120 cases of patients with acute myocardial infarction treated by PCI were divided into the control group and the observation group according to the random number table method， 60 cases in each group. The control group was given routine continuous nursing， and the observation group was given Chinese medicine comprehensive continuous nursing based on Wechat platform. Three months after discharge， the nursing satisfaction， the knowledge awareness of myocardial infarction，the treatment compliance and the attack and duration of angina pectoris in the two groups were compared. Before and after intervention，the changes in scores of Self-rating Anxiety Scale(SAS) and Self-rating Depressing Scale(SDS) in the two groups were compared. Results：The nursing satisfaction rate was 93.33% in the observation group and 78.33% in the control group， the difference being significant(P＜0.05). After intervention， the knowledge awareness of myocardial infarction and the treatment compliance in the observation group were higher than those in the control group，and the attack and duration of angina pectoris were less then those in the control group， differences being significant(P＜0.05). Before intervention，there was no significant difference being found in the comparison of scores of SAS and SDS between the two groups(P＞0.05). After treatment，the scores of SAS and SDS in the two groups were decreased when compared with those before intervention(P＜0.05)， and the two scores in the observation group were lower than those in the control group(P＜ 0.05). Conclusion：Based on Wechat platform，Chinese medicine comprehensive continuous nursing for discharged patients after PCI can improve the nursing satisfaction， the knowledgeawareness of myocardial infarction， the treatment compliance，the symptoms of angina pectoris and bad emotions of patients.