Abstract：This paper discusses the relationship between menopausal syndrome and “the kidney” in Chinese medicine and immune function in modern medicine from its etiology，pathogenesis and symptoms. According to the theory of Prof. LU Qibin， it is pointed out that the pathogenesis of most patients with menopausal syndrome is the deficiency of kidney- yin depletion complicated with vigorous heart- liver fire. The treatment should focus on nourishing yin and tonifying the kidney， taking clearing the liver and soothing the heart as well as calming the mind into account，so as to achieve the interaction of the heart and the kidney and the coordination between water and fire. Combined with modern medical theory， attention should be paid to the influence of low immune function on patients， and improving immunity is helpful to lessen the discomfort symptoms of menopausal syndrome. In addition，special attention should be paid to the psychological guidance to patients， making them treat menopausal syndrome correctly and seriously cooperate with the doctor， and in this way， a good curative effect can be achieved.