肾衰宁胶囊联合瑞格列奈片治疗糖尿病肾病临床研究
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Clinical Study on Shenshuai'ning Capsules Combined with Repaglinide Tablets for Diabetic Nephropathy
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    摘要:

    目的:观察肾衰宁胶囊联合瑞格列奈片治疗糖尿病肾病的临床疗效。方法:选取120 例糖尿病肾病患者,采用随机数字表法分为对照组和观察组各60 例。对照组在常规治疗基础上口服瑞格列奈片,观察组在对照组基础上增服肾衰宁胶囊,2 组均治疗8 周。比较2 组临床疗效、血糖水平、肾功能及炎性因子。结果:观察组总有效率为90.00%,高于对照组73.33%,差异有统计学意义(P<0.05)。治疗前,2 组血糖水平比较,差异无统计学意义(P>0.05)。治疗后,2 组空腹血糖(FBG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbAlc) 水平低于治疗前(P<0.05),但组间比较,差异无统计学意义(P>0.05)。治疗前,2 组血尿素氮(BUN)、血清胱抑素C(CysC)、尿白蛋白排泄率(UAER)、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-18(IL-18) 水平比较,差异均无统计学意义(P>0.05)。治疗后,2 组BUN、CysC、UAER、IL-6、IL-18 水平低于治疗前,且观察组BUN、CysC、UAER、IL-6、IL-18 水平低于对照组,差异均有统计学意义(P<0.05)。结论:肾衰宁胶囊联合瑞格列奈治疗糖尿病肾病疗效显著,可有效调节患者血糖水平,减轻炎性反应,改善肾功能,且安全性高。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Shenshuai'ning capsules combined with repaglinide tablets for diabetic nephropathy. Methods:A total of 120 cases of patients with diabetic nephropathy were divided into the control group and the observation group according to the random number table method,60 cases in each group. The control group was given oral administration of repaglinide tablets based on routine treatment,and the observation group was additionally treated with Shenshuai'ning capsules based on the treatment of the control group. Both groups were treated for eight weeks. The clinical effect,blood glucose levels,kidney function and inflammatory factors in the two groups were compared. Results: The total effective rate was 90.0% in the observation group,higher than that of 73.33% in the control group,the difference being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of blood glucose levels between the two groups(P>0.05). After treatment, the levels of fasting blood glucose(FBG), postprandial 2-hour blood glucose(P2hBG) and hemoglobin A1c(HbA1c) in the two groups were lower than those before treatment(P<0.05), but there was no significant difference being found between the groups(P>0.05). Before treatment,there was no significant difference being found in the comparison of the levels of blood urea nitrogen(BUN),serum cystatin C(CysC),urinary albumin excretion rate(UAER), tumor necrosis factor- α(TNF- α), interleukin-6(IL-6) and interleukin-18(IL-18) between the two groups(P>0.05). After treatment, the levels of BUN, CysC, UAER, IL- 6 and IL- 18 in the two groups were lower than those before treatment, and the levels in the observation group were lower than those in the control group, differences being significant(P<0.05). Conclusion:Shenshuai'ning capsules combined with repaglinide tablets for diabetic nephropathy has significant curative effect,and can effectively regulate blood glucose levels,relieve inflammatory responses and improve kidney function,with high safety.

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邱锋平,朱华艳.肾衰宁胶囊联合瑞格列奈片治疗糖尿病肾病临床研究[J].新中医,2021,53(14):81-84

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  • 在线发布日期: 2021-07-24
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