Abstract： Objective： To observe the effect of Xueshuantong injection on deep vein thrombosis(DVT) of lower limbs. Methods：A total of 150 DVT patients were selected and divided into the observation group and the control group，75 cases in each group. The control group was treated with low molecular weight heparin and the observation group was additionally treated with Xueshuantong injection based on the treatment of the control group. The clinical effect in the two groups was observed. The changes of ulcer area，Visual Analogue Scale(VAS)，Wells Quantitative Score，activated partial thrombin time (APTT)， D- dimer(D- D)， serum interleukin- 8(IL- 8)， intercellular adhesion molecule- 1(ICAM- 1) and hypersensitive Creactive protein(hs- CRP) and the incidence of complications were compared between the two groups. Results： After treatment，the total effective rate was 93.33% in the observation group，higher than that of 81.33% in the control group(P＜ 0.05). The incidence of deep vein valve insufficiency and lower extremity varicose veins in the observation group was lower than that in the control group(P＜0.05). Compared with the same group before treatment，the ulcer area was decreased in the two groups after treatment(P＜0.05)；the VAS score，Wells Quantitative Score and levels of D-D，IL-8，ICAM-1 and hs- CRP were all decreased(P＜0.05)， and APTT levels were increased(P＜0.05). Compared with the control group after treatment，the ulcer area was smaller in the observation group(P＜0.05)；the VAS score，Wells Quantitative Score and levels of D- D， IL- 8， ICAM- 1 and hs- CRP were all lower(P＜0.05)， and APTT levels were higher(P＜0.05). Conclusion： Xueshuantong injection has significant curative effect on DVT patients， which can effectively relieve the clinical symptoms and signs， improve the coagulation function and inflammatory response， and reduce the incidence of deep vein valve insufficiency and superficial varicose veins of lower limbs.