Abstract ： Damp- heat ， deficiency and blood stasis of spleen and stomach are important pathogenesis of precancerous lesions of gastric cancer(PLGC). Among them， the main pathogenesis of PLGC at the the early and middle stages is the dampness-heat of spleen and stomach. The formation of syndrome of dampness-heat of spleen and stomach is mainly related to exogenous pathogenic factors(such as Helicobacterpylori infection)， personal constitution， climate and seasons，location，dietary structure，emotions and other factors. The treatment is mainly to clear and dissolve dampnessheat， and to regulate qi， relax the collaterals and fortify the spleen. In the late stage of PLGC， the pathogenesis is dampness-heat forming into deficiency and stasis ， and mixed with both deficiency and stasis. Therefore ， the main treatment principle is to fortify the spleen and supplement the kidney，disperse stasis and unblock collaterals，and to clear dampness- heat and residual pathogenic factors. Treating PLGC from dampness- heat，deficiency and stasis of spleen and stomach is of great significance for the secondary prevention of gastric cancer.