Abstract： Objective： To observe the clinical effect of modified Banxia Xiexin tang combined with FOLFOX scheme (oxaliplatin， calcium folinate， and fluorouracil) for patients with colorectal cancer with syndrome of cold- heat complex. Methods：A total of 78 cases of patients with colorectal cancer with syndrome of cold-heat complex were randomly divided into the control group and the experiment group，39 cases in each group. After the related indexes of hospitalized patients were normal in the reexamination， the control group was given routine treatments of western medicine and FOLFOX scheme，and the experiment group was additionally treated with modified Banxia Xiexin tang based on the treatment of the control group. Before and after treatment，scores of Chinese medicine syndrome and Karnofsky(KPS)，as well as the levels of carcinoembryonic antigen(CEA)，inflammatory factor interferon-γ(INF-γ)，interleukin-2(IL-2)，and interleukin-6(IL-6) in serum were compared between the two groups. After treatment， the total effective rate and the incidence of adverse reactions were compared between the two groups. Results： When compared with those before treatment in the same group，Chinese medicine syndrome scores，as well as levels of CEA，INF- γ，IL- 2 and IL- 6 in serum in the two groups were decreased after treatment(P＜0.05)， and scores of KPS were increased(P＜0.05). After treatment， when compared with those in the control group，Chinese medicine syndrome scores，as well as levels of CEA，INF- γ，IL- 2 and IL- 6 in serum in the experiment group were lower(P＜0.05)， and score of KPS was higher(P＜0.05). After treatment， the total effective rate was 94.87% in the experiment group， higher than that of 79.49% in the control group(P＜0.05). After treatment，the total incidence of adverse reactions was 12.82% in the experiment group，lower than that of 58.97% in the control group(P＜0.05). Conclusion： In the treatment of patients with colorectal cancer with the syndrome of cold- heat complex，the therapy of modified Banxia Xiexin tang combined with FOLFOX scheme can more safely improve the liver and the kidney function，enhance clinical effect by down-regulating levels of INF-γ，IL-2，IL-6，and CEA in serum.