Abstract：Objective：To observe the effect of comprehensive Chinese medicine nursing combined with music therapy on sleep disorders，cardiovascular complications，and quality of life of senile patients with hemodialysis. Methods：A total of 94 cases of senile patients who received hemodialysis were divided into the control group and the observation group according to the random number table method，47 cases in each group. The control group was given music therapy based on routine nursing，and the observation group was additionally given intervention of comprehensive Chinese medicine nursing based on the nursing of the control group. Changes in scores of Self- rating Anxiety Scale(SAS)，World Health Organization Quality of Life-100(WHOQOL-100) Assessment，and Pittsburgh Sleep Quality Index(PSQI) were observed and compared in the two groups before and after intervention. The incidence of complications in the two groups was observed and compared during treatment. Results： Before treatment， there was no significant difference being found in the comparison of SAS scores between the two groups(P＞0.05). After treatment，SAS scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the score in the observation group was lower than that in the control group(P＜ 0.05). Before treatment， there was no significant difference being found in the comparison of each score of quality of life between the two groups(P＞0.05). After treatment，scores of physical health，psychological health，independence ability， social relationships，personal beliefs，and environment in the two groups were increased when compared with those before treatment(P＜0.05)， and each score in the observation group was higher than that in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of PQSI scores between the two groups(P＞ 0.05). After treatment， PQSI scoresin the two groups were decreased when compared with those before treatment(P＜ 0.05)， and the score in the observation group was lower than that in the control group(P＜0.05). After treatment， the incidences of arrhythmia， heart failure， and hypotension in the observation group were lower than those in the control group， differences being significant(P＜0.05). Conclusion： The intervention of comprehensive Chinese medicine nursing combined with music therapy on senile patients with hemodialysis conduces to improving negative emotions，sleep quality and quality of life，and reducing the incidence of cardiovascular complications.