Abstract：Objective：To observe the effect of Chinese medicine health management on clinical symptoms and quality of life of patients with knee osteoarthritis. Methods：A total of 140 cases of patients with knee osteoarthritis were selected and divided into the control group and the observation group according to the random number table method， 70 cases in each group. The control group was given routine joint rehabilitation management，and the observation group was additionally given Chinese medicine health management based on the treatment of the control group. Before and after treatment，the scores of clinical symptoms and Visual Analogue Scale(VAS) for pain as well as quality of life were compared between the two groups. Results： Before treatment， there was no significant difference being found in the comparison of each score of clinical symptoms between the two groups(P＞0.05). After treatment， each score of clinical symptoms in the two groups was decreased when compared with that before treatment，and each score in the observation group was lower than that in the control group， differences being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of each score of quality of life between the two groups(P＞0.05). After treatment，each score of quality of life in the two groups was increased when compared with that before treatment，and each score in the observation group was higher than that in the control group， differences being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the score of VAS between the two groups(P＞0.05). On the 14th，30th，and 60th day after treatment，the scores of VAS in the two groups were gradually decreased，and the scores in the observation group were lower than those in the control group at the same time point， differences being significant(P＜0.05). Conclusion： Chinese medicine health management can improve clinical symptoms of patients with knee osteoarthritis， enhance their quality of life，and relieve pain.