Abstract：Objective：To observe the clinical effect of Shuxuening injection for acute cerebral infarction. Methods：A total of 90 cases of patients with Shuxuening injection were divided into the control group and the observation group by the oddeven number grouping method according to their tail number of bed number，45 cases in each group. Both groups were given routine treatment including control of blood pressure and blood glucose as well as intracranial dehydration；the control group was additionally treated with dual antiplatelet drugs，and the observation group was additionally given intravenous injection with Shuxuening injection. Both groups were treated for two weeks. The levels of inflammatory factors in serum and the cerebral hemodynamic indexes in both sides before and after treatment as well as the clinical effect in the two groups were observed and compared. Results：The total effective rate was 95.56% in the observation group and 86.67% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of C- reactive protein(CRP)， interleukin- 6(IL- 6) and interleukin- 8(IL- 8) in serum between the two groups(P＞0.05). After treatment，the levels of CRP，IL-6 and IL-8 in the two groups were decreased when compared with those before treatment(P＜0.05)，and the indexes in the observation group were lower than those in the control group(P＜ 0.05). Before treatment， there was no significant difference being found in the comparison of maximum velocity， mean velocity and perfusion indexes of cerebral blood flow in both sides between the two groups(P＞0.05). After treatment，the maximum velocity and mean velocity of cerebral blood flow in both sides in the two groups were increased when compared with those before treatment(P＜0.05)，and the blood perfusion indexes were decreased(P＜0.05)；the improvement of the above indexes in the observation group was more significant than that in the control group(P＜0.05). Conclusion：Shuxuening injection for acute cerebral infarction can effectively improve neurological function of patients， reduce inflammatory reactions，promote blood circulation in the brain，so as to improve the clinical effect.