Abstract：Objective：To observe the effect of Huangmu Erbai tang on clinical symptoms，blood biochemical indexes and urinary biochemical indexes of children with nephrotic syndrome complicated with edema. Methods：A total of 84 cases of children with nephrotic syndrome complicated with edema were selected as the study objects，and randomly divided into the control group and the observation group，42 cases in each group. The control group was given routine treatment，and the observation group was additionally treated with Huangmu Erbai tang based on the treatment of the control group. The curative effective rate was compared between the two groups. Before and after treatment， Chinese medicine syndrome scores， platelet count blood(BPC)， D- dimer(D- D)， fibrinogen(FIB)， activated partial thromboplastin time(APTT)， prothrombin time(PT)，the content of 24- hour urine protein(24 hUP)，serum creatinine(SCr)，blood urea nitrogen(BUN)，and creatinine clearance rate(CCr) were compared between the two groups. The recurrence rate of edema and the incidence of complications were counted in the two groups during treatment and follow-up. Results：The total effective rate was 97.62% in the observation group， higher than that of 85.71% in the control group(P＜0.05). When compared with those before treatment in the same group，Chinese medicine syndrome scores，DD，FIB，24 h UP，SCr，and BUN in the two groups were decreased after treatment(P＜0.05)， and levels of APTT， PT， and CCr were increased(P＜0.05). After treatment， when compared with those in the control group，Chinese medicine syndrome scores，DD，FIB，24 h UP，SCr，and BUN in the observation group were lower after treatment(P＜0.05)，and levels of APTT，PT，and CCr were higher(P＜0.05). During the follow-up，the recurrence rate of edema was 33.33% in the control group，higher than that of 7.32% in the observation group(P＜0.05). During treatment and follow-up，the incidence of complications was 4.76% in the observation group，lower than that of 19.05% in the control group(P＜0.05). Conclusion： Huangmu Erbai tang has a significant curative effect on children with nephrotic syndrome complicated with edema；it can effectively improve their clinical symptoms，and reduce the recurrence rate of edema and the incidence of complications.