Abstract： Objective： To discuss the effect of Yifei Xuanfei Jiangzhuo granules of Chinese medicine on lipoproteinassociated phospholipase A2(LP- PLA2)，homocysteine(Hcy)，matrix metalloproteinase- 9(MMP- 9) in plasma，and carotid plaque of patients with cerebral infarction. Methods： A total of 66 cases of patients who were treated at Pingyu People's Hospital in Henan Province within 12- 72 hours after the onset of cerebral infarction were selected， and divided into the routine treatment group and the Chinese medicine group according to the random number table method，33 cases in each group. The routine treatment group was given routine treatment of cerebral infarction at acute stage， and the Chinese medicine group was additionally given Yifei Xuanfei Jiangzhuo granules of Chinese medicine based on the treatment of the control group. Before treatment as well as after one-month and six-month treatment，changes in levels of Lp-PLA2，Hcy， and MMP- 9 is plasma were detected in the two groups. After six- month treatment， changes in carotid intima- media thickness(IMT)，the numbers and size of plaque were detected in the two groups. Before and after treatment，changes in the score of National Institutes of Health Stroke Scale(NIHSS) were compared between the two groups. Results： Before treatment，there was no significant difference being found in the comparison of the level of plasma MMP-9 between the two groups(P＞0.05). After one month and six-month treatment，levels of plasma MMP-9 in the two groups were decreased(P＞ 0.05)， and the decrease in the Chinese medicine group was more significant than that in the routine treatment group(P＜ 0.05). Before treatment， there was no significant difference being found in the comparison of the level of plasma Hcy between the two groups(P＞0.05). After treatment， levels of plasma Hcy in the two groups were decreased at different degrees(P＜0.05)，and the decrease in the Chinese medicine group was more significant than that in the routine treatment group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the level of plasma Lp- PLA2 between the two groups(P＞0.05). After treatment， levels of plasma Lp- PLA2 in the two groups were decreased(P＜0.05)，and the decrease in the Chinese medicine group was larger than that in the routine treatment group， the difference being significant(P＜0.05). Before treatment， when compared IMT value， the numbers and size of plaque evaluated by carotid ultrasonography between the two groups，there was no significance in the difference(P＞0.05). After sixmonth， IMT values， the numbers and size of plaque reexamined by carotid ultrasonography in the two groups were decreased when compared with those before treatment， the difference being significant(P＜0.05)， and the decrease of the three indexes in the Chinese medicine group was more significant than that in the routine treatment group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the score of NIHSS between the two groups(P＞0.05). After one month and six-month treatment，scores of NIHSS in the two groups showed a downward trend， the difference being significant(P＜0.05)，and the improvement of the score in the Chinese medicine group was better than that in the routine treatment group(P＜0.05). Conclusion： Yifei Xuanfei Jiangzhuo granules of Chinese medicine can significantly reduce levels of Lp- PLA2， Hcy， and MMP- 9 of patients with cerebral infarction. It has better effects on antioxidation，blood flow improvement，and plaque stabilization.