Abstract：Objective：To observe the effect of thumbtack needle on postoperative pain and hip joint function in patients undergoing hip replacement. Methods：A total of 80 cases of patients undergoing hip replacement were randomly divided into the control group and the observation group， 40 cases in each group. The control group was treated with multimodal analgesia and patient- controlled intravenous analgesia，and the observation group was additionally treated with thumbtack needle based on the treatment of the control group. Pain degree，hip joint function and serum inflammatory factors before and after treatment in the two groups were compared， and adverse reactions were recorded. Results： At one week after operation，the Harris scores in the observation group were higher than those in the control group(P＜0.05). At 3th， 6th， 12th and 24th hour after operation respectively，the scores of Numerical Rating Scale(NRS) of pain in the observation group were lower than those in the control group(P＜0.05)；at 36th hour after operation，there was no significant difference being found in the comparison of NRS scores between the two groups(P＞0.05). After treatment， the levels of interleukin- 1β(IL- 1β)， tumor necrosis factor-α(TNF-α) and adiponectin(ADP) in serum in the observation group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 12.50% in the observation group，lower than that of 32.50% in the control group(P＜0.05). Conclusion： The application of thumbtack needle can relieve postoperative pain of patients undergoing hip replacement， lower the level of inflammatory factors in serum， which benefits the recovery of hip joint function with high safety.