Abstract：Objective：To observe the clinical effect of Tongdu Tiaoshen acupuncture and moxibustion method combined with isokinetic muscle strength training for hemiplegia due to cerebral infarction. Methods：A total of 80 cases of patients with hemiplegia due to cerebral infarction were selected and randomly divided into the observation group and the control group， 40 cases in each group. The control group was given isokinetic muscle strength training， and the observation group was additionally treated with Tongdu Tiaoshen acupuncture and moxibustion method combined with isokinetic muscle strength training. The clinical effect was compared between the two groups. Before and after treatment，scores of National Institutes of Health Stroke Scale(NIHSS)， modified Barthel Index(MBI)， as well as levels of muscle strength index and serum index were compared between the two groups. Results： The total effective rate was 85.00% in the observation group， and 65.00% in the control group，the difference being significant(P＜0.05). After treatment，scores of NIHSS in the two groups were decreased when compared with those before treatment(P＜0.05)，and MBI scores were increased(P＜0.05). Score of NIHSS in the observation group was lower than that in the control group(P＜0.05)，and MBI score was higher(P＜0.05). After treatment，peak torque(PT)，average power(AP)，and total work(TW) in the two groups were increased when compared with those before treatment(P＜0.05)，and the three indexes in the observation group were higher than those in the control group (P＜0.05). After treatment，levels of C- reactive protein(CRP) in serum in the two groups were decreased when compared with those before treatment(P＜0.05)，and levels of nerve growth factor(NGF) and brain-derived neurotrophic factor(BDNF) in serum were increased when compared with those before treatment(P＜0.05)；CRP level in serum in the observation group was lower than that in the control group(P＜0.05)，and levels of NGF and BDNF in serum were higher than those in the control group(P＜0.05). Conclusion： For patients with hemiplegia due to cerebral infarction， the therapy of Tongdu Tiaoshen acupuncture and moxibustion method combined with isokinetic muscle strength training can effectively improve their neurological function，ability of daily living，and muscle strength.