Abstract：Objective：To observe the curative effect of modified Erzhi pills and Zhibai Dihuang pills combined with routine therapy for nephrotic syndrome with liver-kidney yin deficiency syndrome and its effect on levels of high-sensitivity C- reactive protein(hs- CRP) and tumor necrosis factor(TNF) - α in serum. Methods： A total of 88 cases of patients with nephrotic syndrome were divided into the control group and the observation group according to the random number table method， 44 cases in each group. Both groups were given routine basic treatment measures； the control group was additionally treated with prednisone， and the observation group was additionally treated with Erzhi pills and Zhibai Dihuang pills based on the treatment of the control group. Both groups were treated for six months. The changes in kidney function indexes， symptom scores of liver- kidney yin deficiency syndrome and levels of hs- CRP and TNF- α in serum before and after treatment as well as the clinical effect and adverse reactions in the two groups were compared. The clinical effect was compared between the two group. Results：After treatment，the albumin in serum in the two groups were increased when compared with those before treatment， and twenty- four- hour urinary protein， blood urea nitrogen and serum creatinine were decreased(P＜0.01)；the albumin in serum in the observation group was higher than that in the control group(P＜0.01)， and the other three indexes were lower(P＜0.01). After treatment，the symptom scores of edema，vertigo，xerostomia，dry throat pain， vexation and irritability， and sore waist in the two groups were decreased when compared with those before treatment(P＜0.01)， and the six symptom scores in the observation group were lower than those in the control group(P＜ 0.01). After six- month treatment，the total effective rate was 93.18％ in the observation group and 72.73％ in the control group， the difference being significant(P＜0.05). The levels of hs- CRP and TNF- α in serum in the two groups were decreased when compared with those before treatment(P＜0.01)，and the two levels in the observation group were lower than those in the control group(P＜0.01). During treatment，the incidence of adverse reactions was 50％ in the observation group and 75％ in the control group，the difference being significant(P＜0.05). Conclusion：Erzhi pills and Zhibai Dihuang pills combined with routine therapy has significant curative effect in treating nephrotic syndrome with liver- kidney yin deficiency syndrome，and can relieve inflammatory responses in the body，reduce kidney injury and effectively decrease the adverse reactions caused by hormones.