Abstract： Objective： To observe the effect of Shexiang Tongxin dropping pills combined with nicorandil injection on plasma endothelin- 1(ET- 1)，plasma high- sensitivity C- reactive protein(hs- CRP)，and the heart function of patients with acute myocardial infarction after percutaneous coronary intervention(PCI). Methods：A total of 82 cases of patients with acute myocardial infarction after PCI surgery were selected and divided into the observation group and the control group according to the random number table method，41 cases in each group. Both groups were treated with PCI surgery. After surgery，the control group was given nicorandil injection，and the observation group was additionally given Shexiang Tongxin dropping pills based on the treatment of the control group. The clinical effect was compared between the two groups. The changes in levels of myocardial enzyme，N-terminal pro-B type natriuretic peptide(NT-proBNP)，ET-1，and hs-CRP，as well as in the heart function were evaluated before and after treatment. Results：The total effective rate was 92.68% in the observation group， higher than that of 70.73% in the control group，the difference being significant(P＜0.05). Before treatment，when compared levels of creatine kinase isoenzyme(CK-MB)，cardiac troponin T(cTnT)，NT-proBNP，ET-1，and hs-CRP between the two groups， there was no significance being found in the difference(P ＞ 0.05). After treatment， levels of CK- MB， cTnT， NT-proBNP，ET-1，and hs-CRP in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above levels in the observation group were lower than those in the control group(P＜0.05). Before treatment，when compared left ventricle ejection fraction(LVEF) and left ventricular end- diastolic diameter(LVEDD) between the two groups， there was no significance being found in the difference(P＞0.05). After treatment， LVEF levels in the two groups were increased when compared with those before treatment，and LVEDD levels were decreased(P＜0.05). After treatment，LVEF level in the observation group was higher than that in the control group，and LVEDD level was lower(P＜0.05). Conclusion： The therapy of Shexiang Tongxin dropping pills combined with nicorandil injection has a good curative effect on patients with acute myocardial infarction after PCI surgery， which can reduce the levels of ET- 1， hs- CRP and myocardial enzyme in plasma，and improve their heart function.