基于定量血流分数评价宽胸气雾剂治疗冠状动脉临界病变临床研究
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R256.22

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Evaluation of Clinical Study of Kuanxiong Aerosol on Critical Coronary Artery Lesions Based on Quantitative Flow Ratio
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    摘要:

    目的:基于定量血流分数评价宽胸气雾剂治疗冠状动脉临界病变的临床疗效。方法:选取43 例冠心病不稳定型心绞痛患者,按随机数字表法分为试验组22 例和对照组21 例。先采集冠状动脉造影(CAG) 图像,试验组连续给予舌下喷服宽胸气雾剂,对照组给予舌下喷服0.9%氯化钠溶液,5 min 后,重新造影并采集图像。比较2 组治疗前后定量血流分数(QFR)、视觉模拟评分法(VAS) 评分,以及试验组治疗前后冠状动脉血流速度。结果:治疗后,2 组QFR 比较,差异无统计学意义(P>0.05)。治疗后,试验组VAS 评分较治疗前降低(P<0.05),且低于同期对照组(P<0.05)。对照组治疗前后VAS 评分比较,差异无统计学意义(P>0.05)。选取8 例试验组患者行冠状动脉血流速度分析,其中5 例患者较治疗前改善,2 例患者同前,1 例患者较治疗前下降。试验组治疗前后冠状动脉平均血流速度比较,差异有统计学意义(P<0.05)。结论:宽胸气雾剂可有效改善心绞痛患者的即时症状和冠状动脉血流速度,对改善冠状动脉微循环有一定作用。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Kuanxiong aerosol on critical coronary artery lesions based on quantitative flow ratio(QFR). Methods: A total of 43 patients with unstable angina pectoris of coronary heart disease were selected and divided into the experiment group and the control group according to random number table method, 22 and 21 cases in each group respectively. The coronary angiography(CAG) images were firstly collected. The experiment group was continuously sprayed with Kuanxiong aerosol under the tongue, while the control group was sprayed with 0.9% sodium chloride solution under the tongue. After five minutes, the images were re- angiographed and collected. The QFR, the scores of Visual Analogue Scale(VAS) between the two groups and coronary blood flow velocity in the experiment group were compared before and after treatment. Results:After treatment,there was no significant difference in QFR between the two groups(P>0.05). After treatment,the VAS score in the experiment group was decreased when compared with that before treatment(P<0.05), and was lower than that in the control group at the same period(P<0.05). There was no significant difference in the VAS scores in the control group before and after treatment(P>0.05). Eight patients in the experiment group were selected for the analysis of coronary blood flow velocity,of which five patients were improved when compared with that before treatment,and two patients were the same. There was significant difference in the comparison of the average blood flow velocity of the coronary artery before and after treatment in the experiment group(P<0.05). Conclusion: Kuanxiong aerosol can effectively improve the immediate symptoms and coronary blood flow velocity of patients with angina pectoris,and has a certain effect on improving coronary microcirculation.

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赖冬梅,王创畅,陈亚辉,何志凌,王侠.基于定量血流分数评价宽胸气雾剂治疗冠状动脉临界病变临床研究[J].新中医,2021,53(16):54-57

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  • 在线发布日期: 2021-08-23
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