九味镇心颗粒联合氟哌噻吨美利曲辛片治疗心脾两虚型神经衰弱临床研究
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R749.71

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Clinical Study on Jiuwei Zhenxin Granules Combined with Flupentixol and Melitracen Tablets for Neurasthenia of Heart-Spleen Deficiency Type
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    摘要:

    目的:观察九味镇心颗粒联合氟哌噻吨美利曲辛片治疗心脾两虚型神经衰弱的临床疗效。方法:将82 例神经衰弱患者按随机数字表法分为对照组及观察组各41 例。对照组给予氟哌噻吨美利曲辛片,观察组在对照组治疗基础上给予九味镇心颗粒,2 组均连续治疗4 周。比较2 组治疗前后心理情绪评分[90 项症状自评量表(SCL-90)、汉密尔顿抑郁量表(HAMD-17)]、匹兹堡睡眠质量指数(PSQI) 评分、心脾两虚证症状评分,观察2 组临床疗效。结果:观察组总有效率为95.12%,对照组为75.61%,2 组比较,差异有统计学意义(P<0.05)。2 组SCL-90 及HAMD-17 评分均较治疗前减少(P<0.01),观察组上述2 项评分均低于对照组(P<0.01)。2 组PSQI 5 项评分均较治疗前降低(P<0.01),观察组PSQI 5 项评分均低于对照组(P<0.01)。2 组心脾两虚证6 项症状评分均较治疗前降低(P<0.01),观察组6 项症状评分均低于对照组(P<0.01)。结论:九味镇心颗粒联合氟哌噻吨美利曲辛片治疗心脾两虚型神经衰弱的疗效确切,可有效改善抑郁等心理障碍,促进中医证候和睡眠质量好转。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Jiuwei Zhenxin granules combined with flupentixol and melitracen tablets for neurasthenia of heart- spleen deficiency type. Methods: A total of 82 cases of patients with neurasthenia were divided into the control group and the observation group according to the random number table method, 41 cases in each group. The control group was given flupentixol and melitracen tablets, and the observation group was additionally given Jiuwei Zhenxin granules based on the treatment of the control group. Both groups were continuously treated for 4 weeks. Before and after treatment,the scores of psychology,emotions,and Pittsburgh Sleep Quality Index(PSQI),as well as the symptom score of heart- spleen deficiency syndrome and clinical effect were compared between the two groups. Results: The total effective rate was 95.12% in the observation group, and 75.61% in the control group, the difference being significant(P<0.05). The scores of Symptom Checklist-90(SCL-90) and Hamilton Depression Scale-17(HAMD-17) in the two groups were decreased when compared with those before treatment(P<0.01),and the two scores in the observation group were lower than those in the control group(P<0.01). The five scores of PSQI in the two groups were decreased when compared with those before treatment(P<0.01),and the scores above in the observation group were lower than those in the control group(P<0.01). The six symptom scores of heart- spleen deficiency syndrome in the two groups were decreased when compared with those before treatment(P<0.01),and the scores above in the observation group were lower than those in the control group(P<0.01). Conclusion:The therapy of Jiuwei Zhenxin granules combined with flupentixol and melitracen tablets has a defined curative effect in the treatment of neurasthenia of heart-spleen deficiency type. It can effectively relieve the psychological disorders like depression, and promote the improvement of Chinese medicine syndrome and quality of sleep.

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倪燕飞,王国民,陈云郁.九味镇心颗粒联合氟哌噻吨美利曲辛片治疗心脾两虚型神经衰弱临床研究[J].新中医,2021,53(16):70-73

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  • 在线发布日期: 2021-08-23
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