Abstract：Objective：To analyze the clinical medication characteristics of Xiyanping injection for bacillary dysentery based on real world study. Methods：The clinical data of 157 cases of patients with bacillary dysentery was obtained from a large electronic medical record data warehouse， and was counted and analyzed by frequency analysis， regression analysis and other statistical methods. The basic information of drug users and medical advice of Xiyanping injection for the treatment of bacillary dysentery were analyzed. The basic information included age，admission department and discharge condition；the medical advice included administration method，single and daily dosage，disease diagnosis and drug combination. Results： The number of pediatric patients with bacillary dysentery being given Xiyanping injection was the largest， accounting for 76.43%. Among the 153 cases of patients(four cases lacked information and were not included in the analysis)，116 cases were cured，accounting for 75.82%；34 cases were improved，accounting for 22.22%. Patients under 18 years old had the highest cure rate， accounting for 78.72% . The 95% confidence interval for the single dosage of Xiyanping injection was [81.08，129.25]，and the 95% confidence interval for the daily dosage of Xiyanping injection was[78.90，132.52]. With the increase of age， both the single dosage and the daily dosage increased. Antibiotics had the highest frequency of drug combination， accounting for 24.08% ； the next was vitamin， accounting for 13.14% ； Chinese herbal compound Huangliansu tablets accounted for 9.70% ； antipyretic agents were the most frequently used pharmacological category of Chinese medicine. Correlation analysis was conducted on Xiyanping injection combined with two drugs. The highest one is {penicillin and compounds containing β-lactamase inhibitors+penicillin，with the rule support being 8.91% and the degree of confidence being 90.00%. Conclusion：The clinical application of Xiyanping injection for bacillary dysentery is consistent with the expert consensus guidance program. Xiyanping injection has obvious curative effect in treating children with bacillary dysentery. The combination of Chinese and western medicine for bacterial dysentery has high clinical value，and antipyretic agents were often applied in Chinese medicine.