Abstract：Objective：To observe the clinical effect of modified Wenjing Huoxue tang combined with medicated thread moxibustion of Zhuang medicine on the chronic pain in adenomyosis(AM). Methods：A total of 50 patients with AM chronic pain were selected and treated with modified Wenjing Huoxue tang combined with medicated thread moxibustion of Zhuang medicine. Three menstrual cycles were one course of treatment，and a total of two courses of treatment were given. The Visual Analogue Scale(VAS) score，Cox Menstrual Symptom Scale(CMSS) score，VAS score of ovulation pain，duration of ovulation pain， score of chronic pelvic pain， menstrual volume， endometrial thickness， uterine volume， carbohydrate antigen(CA) 125 in serum and quality of life were compared before and after treatment. Results： After one course of treatment and two courses of treatment，the VAS score，score of dysmenorrhea degree in CMSS，score of dysmenorrhea time in CMSS，score of ovulation pain in VAS and score of chronic pelvic pain were all decreased when compared with those before treatment(P＜0.05)；the duration of ovulation pain was shorter than that before treatment(P＜0.05). After one course of treatment and two courses of treatment，the score of Pictorial Blood Loss Assessment Chart(PBAC) of patients and the level of CA125 in serum were decreased when compared with those before treatment(P＜0.05)；the endometrial thickness was decreased when compared with that before treatment(P＜0.05)；there was no significant difference in uterine volume between the patients and before treatment(P＞0.05)；the lower abdominal pain，lumbosacral acid distension，anal swelling， nausea and vomiting， dizziness and fatigue， and sleep were improved when compared with those before treatment(P＜ 0.05)；there was no significant difference in anxiety，social and psychological stress of patients when compared with those before treatment(P＞0.05). Conclusion： The therapy of modified Wenjing Huoxue tang combined with medicated thread moxibustion of Zhuang medicine has a definite effect on AM chronic pain， which can significantly relieve dysmenorrhea symptoms，shorten the duration of dysmenorrhea and ovulation pain，reduce the amount of menstruation，and improve the quality of life.