Abstract： Objective： To observe the clinical effect of Fuwai Ⅳ enema combined with Guizhi Fuling capsules for endometriosis(EM) with syndrome of binding of stasis and toxin ， and its effect on tumor markers. Methods ： A total of 98 cases of EM patients with syndrome of binding of stasis and toxin were selected and randomly divided into two groups， 49 cases in each group. The control group was given the oral administration of Guizhi Fuling capsules，and the observation group was additionally given Fuwai Ⅳ enema based on the treatment of the control group. Before and after treatment， Chinese medicine syndrome score of EM，score of Visual Analogue Scale(VAS) of pain，clinical effect，adverse reactions， the recurrence rate，and the differences in content of cancer antigen 125(CA125) as tumor marker were compared between the two groups. Results： After treatment， the average Chinese medicine syndrome score and score of VAS in the observation group were decreased when compared with those in the control group；with the increase of treatment time，the two scores above in the two groups showed a decreasing trend，and the two scores after six- month treatment were the lowest； differences were significant(P＜0.01). The total clinical effective rate was 91.84% in the observation group， significantly higher than that of 79.59% in the control group，the difference being significant(P＜0.05). The total incidence of adverse reactions was 22.45% in the control group，and 8.16% in the observation group，but there was no significance in the difference(P＞0.05). The recurrence rate was 25.64% in the control group， higher than that of 8.89% in the observation group， but there was no significance in the difference(P＞0.05). After treatment， level of CA125 in the observation group was significantly decreased when compared with that in the control group；with the increase of treatment time，the levels in the two groups showed a decreasing trend， and and the two levels after six- month treatment were the lowest(P＜0.01). Conclusion：The therapy of Fuwai Ⅳ enema combined with Guizhi Fuling capsules has a good clinical effect in the treatment of endometriosis with syndrome of binding of stasis and toxin. It can down- regulate levels of tumor markers， with few adverse reactions，low recurrence rate，and high safety. The therapy is better than simple oral administration of Guizhi Fuling capsules.