地黄饮子联合认知康复治疗帕金森病轻度认知障碍临床研究
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R742.5

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温州市基础性科研项目(Y2020864)


Clinical Study on Dihuang Yinzi Combined with Cognitive Rehabilitation for Mild Cognitive Impairment in Parkinson Disease
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    摘要:

    目的:观察地黄饮子联合认知康复治疗阴阳两虚型帕金森病(PD) 轻度认知障碍的临床疗效。方法:选取82 例PD患者,按1∶1 的比例随机分为对照组和观察组各41 例。对照组给予左旋多巴片与认知康复治疗,观察组在对照组基础上给予地黄饮子,连续治疗8 周。比较2 组帕金森病评定量表(UPDRS)、简易智能精神状态检查量表(MMSE)、日常生活能力量表(ADL)、阴阳两虚证症状评分与临床疗效。结果:与同组治疗前比较,治疗后2 组UPDRS-Ⅰ、UPDRS-Ⅱ、UPDRS-Ⅲ评分、ADL 评分及阴阳两虚证各症状评分均降低(P<0.01),MMSE 评分均升高(P<0.01);与对照组治疗后比较,观察组治疗后UPDRS-Ⅰ、UPDRS-Ⅱ、UPDRS-Ⅲ评分、ADL 评分及两虚证各症状评分均较低(P<0.01),MMSE 评分较高(P<0.01)。观察组总有效率为82.93%,高于对照组的58.54%(P<0.05)。结论:地黄饮子联合认知康复治疗阴阳两虚型PD 轻度认知障碍的疗效显著,能改善患者的运动症状、认知功能障碍、日常生活能力、中医症状。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Dihuang Yinzi combined with cognitive rehabilitation for mild cognitive impairment in Parkinson disease(PD) of yin-yang deficiency type. Methods:A total of 82 cases of PD patients were selected and randomly divided into the control group and the observation group(1∶1),41 cases in each group. The control group was given levodopa tablets and cognitive rehabilitation,and the observation group was additionally given Dihuang Yinzi based on the treatment of the control group. Both groups were continuously treated for eight weeks. The scores of Unified Parkinson Disease Rating Scale(UPDRS), Mini- Mental State Examination(MMSE), and Activity of Daily Living(ADL) were compared between the two groups. Symptom scores of yin- yang deficiency syndrome and clinical effect were compared between the two groups. Results:When compared with those before treatment in the same group,each symptom score of yin-yang deficiency syndrome as well as scores of UPDRS-Ⅰ,UPDRS-Ⅱ,UPDRS-Ⅲ,and ADL in the two groups was decreased after treatment(P<0.01),MMSE scores were increased(P<0.01). After treatment,when compared with those in the control group, each symptom score of yin- yang deficiency syndrome as well as scores of UPDRS- Ⅰ, UPDRS- Ⅱ, UPDRS- Ⅲ, and ADL in the observation group was lower than that in the control group(P<0.01), and MMSE score was higher(P<0.01). The total effective rate was 82.93% in the observation group,higher than that of 58.54% in the control group (P<0.05). Conclusion:The therapy of Dihuang Yinzi combined with cognitive rehabilitation has a significant curative effect on the treatment of mild cognitive impairment in PD of yin- yang deficiency type. It can improve motor symptoms, cognitive impairment,activities of daily living,and Chinese medicine symptoms.

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朱斌,王策,徐青青.地黄饮子联合认知康复治疗帕金森病轻度认知障碍临床研究[J].新中医,2021,53(17):38-41

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  • 在线发布日期: 2021-09-09
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