Abstract:Objective:To observe the clinical effect of modified Xuefu Zhuyu tang for cerebral infarction of qi deficiency with blood stasis type and its effect on the related blood lipid indexes. Methods:A total of 60 cases of patients with cerebral infarction of qi deficiency with blood stasis type were divided into the control group and the observation group according to the random number table method,30 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally treated with modified Xuefu Zhuyu tang based on the treatment of the control group. Neurologic impairment scores, Chinese medicine syndrome scores, coagulation function indexes, blood lipid indexes, inflammatory factors indexes and vascular endothelium related indexes before and after treatment as well as the clinical effect and drug safety after treatment in the two groups were compared. Results: After treatment, National Institutes of Health Stroke Scale(NIHSS) scores, Chinese medicine symptom scores and the levels of prothrombin time(PT), activated partial thromboplastin time(APTT),fibrinogen(Fib),total cholesterol(TC),triglyceride(TG),C-reactive protein(CRP), tumor necrosis factor- α(TNF- α),vascular endothelial growth factor(VEGF),hypoxia- inducible factor- 1α(HIF- 1α),matrix metalloproteinase-9(MMP-9) in serum in the two groups were decreased when compared with those before treatment(P< 0.05);NIHSS score,Chinese medicine symptom score and the levels of PT,APTT,Fib,TC,TG,CRP,TNF-α,VEGF, HIF-1α and MMP-9 in serum in the observation group were lower than those in the control group(P<0.05). After treatment, the total effective rate was 96.67% in the observation group,higher than that of 76.67% in the control group(P<0.05);there was no significant difference being found in the comparison of the incidences of adverse reactions between the two groups (P>0.05). Conclusion:The application of modified Xuefu Zhuyu tang is safe and effective in treating patients with cerebral infarction patients of qi deficiency with blood stasis type,which can promote the improvement of neurological function and coagulation function,effectively regulate blood lipid levels and reduce serological correlation indexes.