血府逐瘀汤加减治疗气虚血瘀型脑梗死临床研究
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R743.33

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2019年度浙江省中医药科技计划项目(2019ZB134)


Clinical Study on Modified Xuefu Zhuyu Tang for Cerebral Infarction of Qi Deficiency with Blood Stasis Type
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    摘要:

    目的:观察血府逐瘀汤加减治疗气虚血瘀型脑梗死的临床疗效及对相关血脂指标的影响。方法:将60 例气虚血瘀型脑梗死患者按照随机数字表法分为对照组与观察组各30 例。对照组实施常规西医治疗,观察组在对照组基础上加用血府逐瘀汤加减治疗。比较2 组治疗前后神经功能缺损评分、中医证候积分、凝血功能指标、血脂指标、炎症因子指标、血管内皮相关指标与治疗后临床疗效及用药安全性。结果:与同组治疗前比较,治疗后2 组美国国立卫生研究院卒中量表(NIHSS) 评分、中医证候积分及血清凝血酶原时间(PT)、活化部分凝血激酶时间(APTT)、纤维蛋白原(Fib)、总胆固醇(TC)、甘油三酯(TG)、C-反应蛋白(CRP)、肿瘤坏死因子-α (TNF-α)、血管内皮生长因子(VEGF)、诱导因子-1α (HIF-1α)、基质金属蛋白酶-9 (MMP-9) 水平均降低(P<0.05);与对照组治疗后比较,观察组治疗后NIHSS 评分、中医证候积分及血清PT、APTT、Fib、TC、TG、CRP、TNF-α、VEGF、HIF-1α、MMP-9 水平均较低(P<0.05)。治疗后,观察组总有效率为96.67%,高于对照组的76.67%(P<0.05);2 组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:采用血府逐瘀汤加减治疗气虚血瘀型脑梗死患者安全有效,可促进神经功能、凝血功能的改善,还可有效调节血脂水平,降低血清学相关指标。

    Abstract:

    Abstract:Objective:To observe the clinical effect of modified Xuefu Zhuyu tang for cerebral infarction of qi deficiency with blood stasis type and its effect on the related blood lipid indexes. Methods:A total of 60 cases of patients with cerebral infarction of qi deficiency with blood stasis type were divided into the control group and the observation group according to the random number table method,30 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally treated with modified Xuefu Zhuyu tang based on the treatment of the control group. Neurologic impairment scores, Chinese medicine syndrome scores, coagulation function indexes, blood lipid indexes, inflammatory factors indexes and vascular endothelium related indexes before and after treatment as well as the clinical effect and drug safety after treatment in the two groups were compared. Results: After treatment, National Institutes of Health Stroke Scale(NIHSS) scores, Chinese medicine symptom scores and the levels of prothrombin time(PT), activated partial thromboplastin time(APTT),fibrinogen(Fib),total cholesterol(TC),triglyceride(TG),C-reactive protein(CRP), tumor necrosis factor- α(TNF- α),vascular endothelial growth factor(VEGF),hypoxia- inducible factor- 1α(HIF- 1α),matrix metalloproteinase-9(MMP-9) in serum in the two groups were decreased when compared with those before treatment(P< 0.05);NIHSS score,Chinese medicine symptom score and the levels of PT,APTT,Fib,TC,TG,CRP,TNF-α,VEGF, HIF-1α and MMP-9 in serum in the observation group were lower than those in the control group(P<0.05). After treatment, the total effective rate was 96.67% in the observation group,higher than that of 76.67% in the control group(P<0.05);there was no significant difference being found in the comparison of the incidences of adverse reactions between the two groups (P>0.05). Conclusion:The application of modified Xuefu Zhuyu tang is safe and effective in treating patients with cerebral infarction patients of qi deficiency with blood stasis type,which can promote the improvement of neurological function and coagulation function,effectively regulate blood lipid levels and reduce serological correlation indexes.

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李洁,郝宗霞,郑萍红,陈琳,李飞泽.血府逐瘀汤加减治疗气虚血瘀型脑梗死临床研究[J].新中医,2021,53(17):42-46

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  • 在线发布日期: 2021-09-09
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