补中益气汤加味联合环孢素治疗封闭抗体异常复发性流产临床研究
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R714.21;R271.9

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温州市科技计划项目(Y2020853)


Clinical Study on Modified Buzhong Yiqi Tang Combined with Cyclosporin for Recurrent Spontaneous Abortion Due to Abnormal Blocking Antibody
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    摘要:

    目的:观察补中益气汤加味联合环孢素治疗封闭抗体异常复发性流产的临床疗效。方法:选取封闭抗体异常复发性流产患者100 例,采用简单随机化法分为治疗组与对照组各50 例。对照组孕后给予环孢素治疗,治疗组孕前给予补中益气汤加味治疗,转阳患者直接受孕并继续给予补中益气汤加味治疗,阴性患者受孕后给予补中益气汤加味联合环孢素治疗,治疗至孕12 周后评估2 组临床疗效、白细胞分化抗原(CD) 转阳率、保胎成功率、安全性及依从性。结果:治疗组临床总有效率为88.10%,优于对照组的65.79%(P<0.05)。治疗后,与对照组比较,治疗组抗CD3-BE、抗CD4-BE、抗CD8-BE 转阳率均较高(P<0.05)。治疗组孕12 周后保胎率高于对照组(P<0.05),流产率低于对照组(P<0.05)。治疗期间,2 组各不良反应发生率、配合完成试验例数、脱落例数与依从性比较,差异均无统计学意义(P>0.05)。结论:对封闭抗体异常复发性流产患者采用补中益气汤加味联合环孢素治疗疗效满意,可有效提高抗CD 抗原转阳率和保胎成功率,药物安全性高,依从性好。

    Abstract:

    Objective:To observe the clinical effect of modified Buzhong Yiqi tang combined with cyclosporin for recurrent spontaneous abortion due to abnormal blocking antibody. Methods: A total of 100 cases of patients with recurrent spontaneous abortion due to abnormal blocking antibody were selected and divided into the treatment group and the control group by simple random sampling,50 cases in each group. The control group was treated with cyclosporin after pregnancy, and the treatment group was given modified Buzhong Yiqi tang before pregnancy. The patients with positive conversion were directly pregnant and continued to be treated with modified Buzhong Yiqi tang. The patients with negative conversion were treated with modified Buzhong Yiqi tang Combined with cyclosporine. The clinical efficacy, positive conversion rate of leukocyte differentiation antigen(CD), successful tocolysis rate, safety and compliance in the two groups were evaluated from the beginning of the treatment to after 12 weeks of pregnancy. Results:The total clinical effective rate was 88.10% in the treatment group,better than that of 65.79% in the control group(P<0.05). After treatment,the positive conversion rates of anti-CD3-BE,anti-CD4-BE,and anti- CD8-BE in the treatment group were higher than those in the control group(P< 0.05). The successful tocolysis rate after 12- week pregnancy in the treatment group was higher than that in the control group(P<0.05), and the abortion rate was lower(P<0.05). During treatment, when compared incidence of adverse reactions,the number of cases that completed the test,the number of cases that dropped out,and compliance between the two groups,there was no significance being found in the difference(P>0.05). Conclusion:In the treatment of patients with recurrent spontaneous abortion due to abnormal blocking antibody,the therapy of modified Buzhong Yiqi tang combined with cyclosporin has satisfying curative effect, high safety, and good compliance, which can effectively enhance the positive conversion rate of anti-CD antigen and successful tocolysis rate.

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钱艳清,诸小丽.补中益气汤加味联合环孢素治疗封闭抗体异常复发性流产临床研究[J].新中医,2021,53(17):46-50

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  • 在线发布日期: 2021-09-09
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