清肺汤联合西药治疗慢性阻塞性肺疾病临床研究
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R563

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Study on Curative Effect of Qingfei Tang Combined with Western Medicine for Chronic Obstructive Pulmonary Disease
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    摘要:

    目的:观察自拟清肺汤对慢性阻塞性肺疾病(COPD) 患者肺功能的影响及其临床疗效。方法:选取92 例COPD 患者,按随机数字表法分为常规治疗组及清肺汤组各46 例。常规治疗组给予常规治疗,包括吸氧、祛痰、雾化吸入等,清肺汤组在常规治疗组基础上给予自拟清肺汤治疗。2 组均连续治疗2 周。比较2 组临床疗效,观察2 组治疗前后肺功能[第1 秒用力呼气容积占预计值百分比(FEV1%)、第1 秒用力呼气量占用力肺活量百分比(FEV1/FVC)] 和血气分析相关指标[动脉血二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)]。比较2 组治疗前后中医证候积分,观察2 组治疗期间不良反应发生情况。结果:清肺汤组总有效率为93.48%,常规治疗组为80.43%,2 组比较,差异无统计学意义(P>0.05)。治疗后,2 组FEV1%、FEV1/FVC水平均较治疗前上升(P<0.01),清肺汤组FEV1%、FEV1/FVC 水平均高于常规治疗组(P<0.01)。治疗后,2 组PaCO2 均较治疗前下降,PaO2 均较治疗前上升;清肺汤组PaCO2 低于常规治疗组,PaO2 高于常规治疗组,差异均有统计学意义(P<0.01)。治疗后,2 组中医证候积分均较治疗前下降(P<0.01),清肺汤组中医证候积分低于常规治疗组(P<0.01)。2 组治疗过程中患者生命体征平稳,且均未发生药物不良反应及过敏反应。结论:自拟清肺汤联合常规西药治疗COPD,能改善患者的肺功能,缓解临床症状,用药安全性较高。

    Abstract:

    Abstract: Objective: To observe the effect of self- made Qingfei tang on lung function of patients with chronic obstructive pulmonary disease(COPD) and its clinical effect. Methods:A total of 92 cases of COPD patients were selected and divided into the treatment group and the routine group according to the random number table method,46 cases in each group. The routine group was given routine treatment,including oxygen inhalation,expectorant and aerosol inhalation,and the treatment group was additionally treated with self-made Qingfei tang based on the treatment of the routine group. Both groups were treated for two weeks. The clinical effect in the two groups was compared; lung function including the percentage of forced expiratory volume in the first second to the predicted value(FEV1% ) and the percentage of forced expiratory volume in the first second to forced vital capacity(FEV1/FVC) as well as the blood gas analysis related indexes including arterial carbon dioxide partial pressure(PaCO2) and arterial oxygen partial pressure(PaO2) before and after treatment in the two groups were observed. Chinese medicine syndrome scores before and after treatment and the incidence of adverse reactions after treatment in the two groups were compared. Results:The total effective rate was 93.48% in the treatment group and 80.43% in the routine group, there being no significant difference between the two groups(P>0.05). After treatment,the levels of FEV1% and FEV1/FVC in the two groups were increased when compared with those before treatment (P<0.01), and the levels in the treatment group were higher than those in the control group(P<0.01). After treatment, PaCO2 levels in the two groups were decreased when compared with those before treatment, and PaO2 levels were increased;PaCO2 in the treatment group was lower than that in the routine group,and PaO2 was higher,differences being significant(P<0.01). After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.01), and the score in the treatment group was lower than that in the routine group(P< 0.01). During treatment, vital signs of patients in the two groups were stable and no adverse drug reactions or allergic reactions occurred. Conclusion:Self-made Qingfei tang can improve the lung function of COPD patients and alleviate clinical symptoms with high medication safety.

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陆杨飞,汪晓波,赵君.清肺汤联合西药治疗慢性阻塞性肺疾病临床研究[J].新中医,2021,53(17):87-90

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  • 在线发布日期: 2021-09-09
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