Abstract：Objective：To observe the clinical effect of Shengmai injection on patients with septic shock in ICU. Methods： A total of 100 patients with septic shock were randomly divided into the control group and the treatment group，50 cases in each group. The control group was treated strictly according to relevant standards，and the treatment group was additionally given Shengmai injection based on the treatment of the control group. The Acute Physiology and Chronic Health Evaluation Ⅱ (APACHEⅡ)，tissue perfusion indexes，the blood lactic acid level were compared between the two groups before and after treatment. The mortality rate and medication safety were compared between the two groups after treatment. Results： Compared with those before treatment，the APACHE II scores in the two groups were decreased after treatment(P＜0.05)， and the levels of central venous pressure(CVP)，mean arterial pressure(MAP)，systemic central venous oxygen(ScvO2) and urine volume were increased(P＜0.05). Compared with that in the control group after treatment，the APACHE II score in the treatment group was lower(P＜0.05)， and the levels of CVP， MAP， ScvO2 and urine volume were higher(P＜0.05). Compared with those before treatment，the blood lactic acid levels in both groups were decreased at 6th，12th，24th and 72nd hours(P＜0.05). Compared with that in the control group，the blood lactic acid level in the treatment group was lower at 6th， 12th，24th and 72nd hours(P＜0.05). The mortality rate on Day 7 in the treatment group was 6.0%，significantly lower than that of 22.0% in the control group(P＜0.05). There was no obvious discomfort and allergy in the two groups during the treatment. Conclusion：Shengmai injection is effective and safe in the treatment of patients with septic shock in ICU.