Abstract： Objective： To observe the clinical effect of Shuluo Yin combined with rosuvastatin calcium for metabolic syndrome(MS) and glucose and lipid metabolism，so as to provide reference for clinical treatment of MS. Methods：A total of 95 cases of MS patients admitted from May 2018 to October 2019 were selected as the study subjects. They were randomly numbered 1 to 95；48 patients with odd numbers were included in the control group，and 47 patients with even numbers were included in the observation group. Both groups were given routine treatment，and the control group was treated with rosuvastatin calcium， and the observation group was additionally treated with Shuluo Yin based on the control group. The curative effect of TCM syndrome， blood glucose and insulin index， blood lipid and safety of medication were observed. Results：Compared with the control group(77.08%)，the total effective rate of the observation group(93.62%) was higher(P＜ 0.05)； compared with before treatment， fasting blood glucose(FBG)， fasting insulin(FINS) and insulin resistance index (HOMA- IR) of both groups after treatment were decreased，and the observation group was lower in comparison with the control group(P＜0.05)；compared with before treatment，triglyceride(TG)，total cholesterol(TC) and low density lipoprotein cholesterol(LDL- C) were decreased，while high density lipoprotein cholesterol(HDL- C) was increased in both groups after treatment， and the improvement in the observation group was more significant(P＜0.05)； there was no severe adverse reaction in both groups during treatment. Conclusion：Based on the lipid-lowering treatment with rosuvastatin calcium，the combination of Shuluo Yin can effectively regulate levels of blood glucose and blood lipid of MS patients， promote the improvement of clinical symptoms，and enhance therapeutic effect in clinic，with high safety of medication.