Abstract： Objective： To observe the clinical effect of Huodan pills for patients with chronic sinusitis during the perioperative period of endoscopic endonasal surgery and its effect on inflammatory factors. Methods：A total of 108 cases of patients with chronic sinusitis were selected and divided into the control group and the observation group according to the random number table method，54 cases in each group. The control group was treated with routine western medicine after endoscopic endonasal surgery，and the observation group was additionally treated with Huodan pills based on the treatment of the control group. The curative effective rate was compared between the two groups. Before and after treatment，changes in interleukin- 6(IL- 6) and interleukin- 2(IL- 2)，the mucociliary clearance(MCC)，and mucociliary transport rate(MTR) were compared between the two groups. Results：After treatment，the total effective rate was 92.59% in the observation group， higher than that of 74.70% in the control group(P＜0.05). When compared with those in the same group before treatment， levels of IL-6 and IL-2 in the two group were decreased after treatment(P＜0.05)，and MCC and MTR were increased(P＜ 0.05). When compared with those in the control group after treatment，levels of IL-6 and IL-2 in the observation group were lower(P＜0.05)， and MCC and MTR were higher(P＜0.05). Conclusion： The therapy of endoscopic endonasal surgery combined with Huodan pills can achieve a good curative effect in the treatment of patients with chronic sinusitis. It can effectively improve levels of inflammatory factors，mucociliary clearance，and mucociliary transport rate.