Abstract： Objective： To observe the clinical effect of Fuzheng Kang'ai tang combined with FOLFOX4 scheme in the treatment of advanced gastric cancer after surgery. Methods：A total of 102 cases of patients with advanced gastric cancer after surgery were retrospectively analyzed. According to different treatment methods， they were divided into the observation group and the control group. The observation group was treated with Fuzheng Kang'ai tang combined with FOLFOX4 scheme， while the control group was only treated with FOLFOX4 scheme. Both groups were treated for two cycles. After two cycles， clinical effect in the two groups was observed. Adverse reactions and quality of life [Karnofsky Performance Status(KPS)， Quality of Life Questionnaire- Core 30(QLQ- C30)] were compared between the two groups. Results：After treatment，objective remission rate(ORR) was 63.46% in the observation group，higher than that of 36.00% in the control group(P＜0.05)；clinical benefit rate(CBR) was 88.46% in the observation group，higher than that of 52.00% in the control group(P＜0.05). During treatment，the incidences of myelosuppression，gastrointestinal reactions and peripheral neurotoxicity in the observation group were lower than those in the control group， differences being significant(P＜0.05). There was no significant difference being found in the comparison of the liver and kidney dysfunction(P＞0.05). After treatment，scores of KPS and QLQ-C30 in the two groups were increased when compared with those before treatment(P＜ 0.05)，and the two scores in the observation group were higher than those in the control group(P＜0.05). Conclusion：The therapy of Fuzheng Kang'ai tang combined with FOLFOX4 scheme in the treatment of advanced gastric cancer after surgery can enhance the clinical effect，reduce the incidence of adverse reactions，effectively improve quality of life，and improve prognosis.