Abstract：Objective：To observe the effect of Yixinshu capsules combined with conventional treatment on non-valvular atrial fibrillation. Methods： Ninety- six patients with non- valvular atrial fibrillation with syndrome of qi- yin depletion and syndrome of heart blood stasis obstruction were included，and divided into the control group and the observation group by random number table method， 48 cases in each group. Patients in the two groups were treated with routine antihypertensive， hypoglycemic， lipid regulation， mentality adjustment， diet and other treatment measures， and were treated with warfarin sodium tablets. The observation group was additionally treated with Yixinshu capsules based on the treatment of the control group. The treatment course of both groups was three months. The changes of coagulation function indexes，onset of atrial fibrillation，level of N-terminal pro brain natriuretic peptide(NT-proBNP) in plasma and hemorheology were observed before and three months after treatment in the two groups. Results：After treatment，the prothrombin time (PT)，activated partial thromboplastin time(APTT)，thrombin time(TT) and international standardized ratio(INR) in both groups were increased when compared with those before treatment(P＜0.01)； PT， APTT， TT and INR in the observation group were longer or higher than those in the control group(P＜0.01). The onset time and frequency of atrial fibrillation in both groups were shorter or lower than those before treatment(P＜0.01)； the onset time and frequency of atrial fibrillation in the observation group were shorter than or lower than those in the control group(P＜0.01). The levels of NT-proBNP in plasma in both groups were decreased when compared with those before treatment(P＜0.01)，and the level of NT-proBNP in plasma in the observation group was lower than that in the control group(P＜0.01). The levels of hematocrit(HCT)， fibrinogen(Fb)， whole blood viscosity and plasma specific viscosity in the two groups were lower than those before treatment(P＜0.01)，and the above four indexes in the observation group were lower than those in the control group(P＜0.01). Conclusion： On the basis of conventional treatment，Yixinshu capsules can be used to treat non-valvular atrial fibrillation with syndrome of qi-yin depletion and syndrome of heart blood stasis obstruction，which has obvious effect on the improvement of the coagulation function，relief of cardiac function and clinical symptoms of patients，and can effectively improve the level of hemorheology.