益心舒胶囊联合常规疗法治疗非瓣膜性心房颤动临床研究
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R541.7+5

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Clinical Study on Yixinshu Capsules Combined with Conventional Treatment for Non- Valvular Atrial Fibrillation
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    摘要:

    目的:观察益心舒胶囊联合常规疗法治疗非瓣膜性心房颤动的疗效。方法:纳入96 例气阴亏虚兼瘀血内阻型非瓣膜性心房颤动患者,采用随机数字表法分为对照组和观察组各48 例。2 组患者均予常规降压、降糖、调脂以及调整心态、饮食等治疗措施,并服用华法林钠片治疗,观察组加予益心舒胶囊治疗。2 组疗程均为3 个月。观察2 组治疗前及治疗3 个月后凝血功能指标、心房颤动发作情况、血浆N 末端B 型利钠肽原(NT-proBNP) 以及血液流变学水平的变化。结果:治疗后,2 组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、国际标准化比值(INR) 均较治疗前增加(P<0.01),观察组PT、APTT、TT、INR 均长于或高于对照组(P<0.01)。2 组心房颤动发作时间与发作频率均较治疗前缩短或降低(P<0.01),观察组心房颤动发作时间与发作频率均短于或低于对照组(P<0.01)。2 组血浆NT-proBNP 水平均较治疗前降低(P<0.01),观察组血浆NT-proBNP 水平均低于对照组(P<0.01)。2 组红细胞比容(HCT)、纤维蛋白原(Fb)、全血黏度、血浆比黏度均较治疗前降低(P<0.01),观察组4 项指标值均低于对照组(P<0.01)。结论:在常规治疗基础上加服益心舒胶囊治疗气阴亏虚兼瘀血内阻型非瓣膜性心房颤动,在改善患者的凝血功能、心功能以及缓解临床症状方面疗效明显,且可有效改善血液流变学水平。

    Abstract:

    Abstract:Objective:To observe the effect of Yixinshu capsules combined with conventional treatment on non-valvular atrial fibrillation. Methods: Ninety- six patients with non- valvular atrial fibrillation with syndrome of qi- yin depletion and syndrome of heart blood stasis obstruction were included,and divided into the control group and the observation group by random number table method, 48 cases in each group. Patients in the two groups were treated with routine antihypertensive, hypoglycemic, lipid regulation, mentality adjustment, diet and other treatment measures, and were treated with warfarin sodium tablets. The observation group was additionally treated with Yixinshu capsules based on the treatment of the control group. The treatment course of both groups was three months. The changes of coagulation function indexes,onset of atrial fibrillation,level of N-terminal pro brain natriuretic peptide(NT-proBNP) in plasma and hemorheology were observed before and three months after treatment in the two groups. Results:After treatment,the prothrombin time (PT),activated partial thromboplastin time(APTT),thrombin time(TT) and international standardized ratio(INR) in both groups were increased when compared with those before treatment(P<0.01); PT, APTT, TT and INR in the observation group were longer or higher than those in the control group(P<0.01). The onset time and frequency of atrial fibrillation in both groups were shorter or lower than those before treatment(P<0.01); the onset time and frequency of atrial fibrillation in the observation group were shorter than or lower than those in the control group(P<0.01). The levels of NT-proBNP in plasma in both groups were decreased when compared with those before treatment(P<0.01),and the level of NT-proBNP in plasma in the observation group was lower than that in the control group(P<0.01). The levels of hematocrit(HCT), fibrinogen(Fb), whole blood viscosity and plasma specific viscosity in the two groups were lower than those before treatment(P<0.01),and the above four indexes in the observation group were lower than those in the control group(P<0.01). Conclusion: On the basis of conventional treatment,Yixinshu capsules can be used to treat non-valvular atrial fibrillation with syndrome of qi-yin depletion and syndrome of heart blood stasis obstruction,which has obvious effect on the improvement of the coagulation function,relief of cardiac function and clinical symptoms of patients,and can effectively improve the level of hemorheology.

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刘峰.益心舒胶囊联合常规疗法治疗非瓣膜性心房颤动临床研究[J].新中医,2021,53(18):41-44

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  • 在线发布日期: 2021-09-24
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