Abstract： Objective： To observe the clinical effect of Shenqi Shiyiwei granules combined with western medicine for chronic obstructive pulmonary disease(COPD) of lung-kidney deficiency type at stable stage. Methods：A total of 106 cases of COPD patients lung- kidney deficiency type at stable stage were selected and divided into the control group and the observation group according to the random number table method， 53 cases in each group. The control group was given tiotropium bromide inhalation powder and theophylline extended- release capsules. The observation group was additionally treated with Shenqi Shiyiwei granules based on the treatment of the control group. Both groups were treated for three months. Before and after treatment， the lung function， immune function， BODE index， and the level of inflammatory factors in serum were compared between the two groups. Results： After treatment， the forced expiratory volume in one second(FEV1)， forced vital capacity(FVC)， levels of CD3 + and CD4 + ， FEV1/FVC， and CD4 +/CD8 + in the two groups were increased when compared with those before treatment(P＜0.05)； BODE index， as well as levels of tumor necrosis factor- α(TNF-α)，interleukin-6(IL-6)，and interleukin-8(IL-8) in serum were decreased when compared with those before treatment(P＜0.05). Levels of FEV1，FVC，CD3+，CD4+，as well as FEV1/FVC，and CD4+/CD8+ in the observation group were higher than those in the control group(P＜0.05)；BODE index，as well as levels of TNF- α，IL- 6 and IL- 8 in serum were lower than those in the control group(P＜0.05). Conclusion： In the treatment of COPD of lung- kidney deficiency type at stable stage， Shenqi Shiyiwei granules combined with western medicine can effectively improve the lung function and immune function，relieve the condition of disease，and inhibit inflammatory responses.