Abstract： Objective： To observe the clinical effect of Bushen Yanggan tang on the treatment of early- stage diabetic kidney disease(DKD) with liver-kidney yin deficiency syndrome. Methods：A total of 258 DKD patients with liver-kidney yin deficiency syndrome were randomly divided into the study group and the control group，129 cases in each group.The control group was treated with routine control of blood glucose and blood pressure，while the study group was treated with Bushen Yanggan tang on the basis of the control group.The two groups were treated for three months. The Chinese medicine syndrome scores before and after treatment were observed and compared between the two groups. Meanwhile，the levels of blood glucose，kidney function injury and inflammatory factors in the two groups were compared and analyzed. Results： The total effective rate was 93.80% in the study group and 83.72% in the control group，the difference being significant(P＜ 0.05). Before treatment， there was no significant difference in the comparison of the Chinese medicine syndrome score between the two groups(P＞0.05). After treatment，the Chinese medicine syndrome scores in both groups were decreased when compared with those before treatment(P＜0.05)，and the syndrome score in the study group was lower than that in the control group(P ＜ 0.05). Before treatment ， there was no significant difference in the comparison of fasting blood glucose(FBG)， 2 h postprandial blood glucose(P2hBG) and HbA1c between the two groups(P＞0.05). After treatment， the levels of FBG，P2hBG and HbA1c in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above levels in the study group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference in the comparison of the levels of urinary microalbumin(mAlb) and serum uric acid(UA) between the two groups(P＞0.05). After treatment， the levels of mAlb and UA in both groups were decreased when compared with those before treatment(P＜0.05)，and the above two levels in the study group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference in the comparison of the levels of Hypersensitive C-reactive protein(hs- CRP)，procalcitonin(PCT) and transforming growth factor-β1(TGF-β1)(P＞0.05). After treatment，the levels of hs-CRP，PCT and TGF-β1 in both groups were decreased when compared with those before treatment(P＜0.05)，and the above levels in the study group were lower than those in the control group(P＜0.05). Conclusion： Bushen Yanggan tang for early- stage DKD，can improve the clinical effect，effectively control the blood glucose level of patients，reduce urinary albumin，and improve the micro-inflammatory state of the body and kidney function injury.