艾复康胶囊联合HAART 治疗艾滋病临床研究
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R512.91

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Clinical Study on Aifukang Capsules Combined with HAART for Acquired Immune Deficiency Syndrome
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    摘要:

    目的:观察艾复康胶囊联合抗逆转录病毒疗法(HAART) 疗法治疗艾滋病的临床疗效。方法:选取90 例艾滋病患者,按入院单双号分为治疗组与对照组,每组45 例。对照组给予HAART 治疗,治疗组在对照组基础上给予艾复康胶囊治疗,2 组均连续治疗6 个月。比较2 组临床疗效及不良反应;比较2 组治疗前后免疫功能、病毒抑制情况、临床结局(PRO) 评分及肝肾功能。结果:治疗组总有效率为91.11%,高于对照组的66.67%(P<0.05)。治疗后,治疗组CD4+水平及CD4+/CD8+均高于对照组(P<0.05);2 组CD8+水平比较,差异无统计学意义(P>0.05);治疗组总胆红素(TBil)、谷丙转氨酶(ALT)、血肌酐(SCr) 水平均低于对照组(P<0.05)。治疗组病毒载量低于对照组(P<0.05);治疗组病毒抑制率为62.22%,高于对照组的40.00%(P<0.05)。治疗组生理领域、心理领域、社会领域评分均低于对照组(P<0.05)。治疗组不良反应发生率为26.67%,低于对照组的48.89%(P<0.05)。结论:艾复康胶囊联合HAART 治疗艾滋病可提高临床疗效,抑制人类免疫缺陷病毒,提高机体免疫力,改善PRO,降低不良反应发生率。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Aifukang capsules combined with highly active anti- retroviral therapy(HAART) on acquired immune deficiency syndrome. Methods: A total of 90 acquired immune deficiecy syndrome patients were selected and divided into the treatment group and the control group according to the odd- even number of admission,45 cases in each group. The control group was treated with HAART,and the treatment group was additionally treated with Aifukang capsules based on the treatment of the control group. Both groups were treated for six months. The clinical effect and adverse reactions were compared between the two groups; the immune function, virus suppression, score of patient reported outcome(PRO),liver and kidney function were compared between the two groups before and after treatment. Results:The total effective rate was 91.11% in the treatment group,higher than that of 66.67% in the control group(P<0.05). After treatment,levels of CD4 + and CD4 +/CD8 + value in the treatment group were higher than those in the control group(P<0.05);there was no significant difference in the CD8+ levels between the two groups(P>0.05);the levels of total bilirubin(TBil),alanine aminotransferase(ALT) and serum creatinine(SCr) in the treatment group were lower than those in the control group(P<0.05). Viral load in the treatment group was smaller than that in the control group(P<0.05);the virus inhibition rate in the treatment group was 62.22%,higher than that of 40.00% in the control group(P<0.05). The scores of physiological field,psychological field and social field in the treatment group were lower than those in the control group(P< 0.05). The incidence of adverse reactions in the treatment group was 26.67%,lower than that of 48.89% in the control group (P<0.05). Conclusion:Aifukang capsules combined with HAART in the treatment of acquired immune deficiency syndrome can improve the clinical effect, inhibit human immunodeficiency virus, improve the body immunity and PRO, reduce the incidence of adverse reactions.

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林丹聚.艾复康胶囊联合HAART 治疗艾滋病临床研究[J].新中医,2021,53(18):95-98

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  • 在线发布日期: 2021-09-24
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