Abstract： Objective： To observe the clinical effect of Chinese medicine comprehensive nursing plan of apoplexy for patients with acute stage of cerebral infarction. Methods：A total of 90 cases of patients with acute stage of cerebral infarction were selected as the research object and divided into the control group and the observation group according to the random number table method，45 cases in each group. The control group was given routine nursing intervention，and the observation group was additionally given Chinese medicine comprehensive nursing plan of apoplexy based on the treatment of the control group. After 28 days of intervention， the clinical effect and nursing satisfaction in the two groups were observed and compared. The symptom scores before and after intervention in the two groups were analyzed. Results：After intervention， the total effective rate was 97.78% in the observation group and 77.78% in the control group，the difference being significant (P＜0.05). Before intervention，there was no significant difference being found in the comparison of the scores of headache and dizziness，facial palsy and hemiplegia as well as the total scores between the two groups(P＞0.05). After intervention， the scores of the above items and the total scores in the two groups were decreased when compared with those before intervention(P＜0.05)，and the above scores in the observation group were lower than those in the control group(P＜0.05). After nursing，the nursing satisfaction was 97.78% in the observation group and 77.78% in the control group，the difference being significant(P＜0.05). Conclusion： The intervention of Chinese medicine comprehensive nursing plan of apoplexy has significant curative effect in treating patients with acute stage of cerebral infarction，which can effectively relieve their clinical symptoms and improve the nursing satisfaction.