Abstract：Objective：To observe the effect of Qingfei Huatan prescription combined with emotional release therapy on emotion， quality of life and blood gas analysis in patients with chronic obstructive pulmonary disease(COPD). Methods： A total of 114 cases of COPD patients were selected and divided into the control group and the observation group according to the random number table method，57 cases in each group. The control group was given emotional release therapy based on routine treatment，and the observation group was additionally given Qingfei Huatan prescription based on the treatment of the control group. The changes of negative emotions，quality of life and blood gas analysis before and after treatment in the two groups were compared. Results：Before treatment，there was no significant difference being found in the comparison of the scores of Self-rating Anxiety Scale(SAS) and Self-rating Depression Scale(SDS) between the two groups(P＞0.05). After treatment，the scores of SAS and SDS in the two groups were decreased when compared with those before treatment(P＜ 0.05)，and the scores in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the scores of physical function， role function， emotional function and social function between the two groups(P＞0.05). After treatment，the scores of quality of life in the two groups were increased when compared with those before treatment(P＜0.05)， and the scores of quality of life in the observation group were higher than those in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of PaO2，PaCO2 and pH between the two groups(P＞0.05). After treatment，the levels of PaO2 and pH in the two groups were increased when compared with those before treatment(P＜0.05)，and the levels of PaCO2 were decreased(P＜0.05)；the improvement of various indexes in the observation group was more significant than that in the control group(P＜0.05). Conclusion： The application of Qingfei Huatan prescription combined with emotional release therapy for COPD patients is helpful to improve the indexes of blood gas analysis and adverse emotions of patients， and enhance their quality of life.