Abstract： Objective： To analyze the population characteristics and clinical medication characteristics of breviscapine injection in the treatment of coronary heart disease(CHD) based on the real world study. Methods： The electronic medical records of breviscapine injection and the first diagnosis of CHD were extracted from the Electronic Medical Record system (EMR) and Hospital Information System(HIS). After extracting and establishing data， SPSS Clementine 21.0 software was used to analyze the general data and the rules of medicine combination. Results： Most of the 9 321 patients with CHD extracted from the systems were aged between 65 and 80 years old(45.24%)，with males slightly more than females. The solar term of the year when most patients were admitted into hospital was Cold Dews(5.74%). Patients with CHD were often complicated with essential hypertension(44.12%)，cerebral infarction(18.14%)，type 2 diabetes mellitus(17.70%)，etc. The Chinese medicine syndromes were mainly deficiency of both qi and yin(13.02% )， liver- kidney depletion(12.78% )， and binding of stasis and phlegm(11.34%)，etc. The frequency of medicine whose single dose exceeded the instruction 5-50 mg was 7 991 cases(58.02% ). In clinical practice， commonly used western medicines were combined with aspirin(14.29% )， metoprolol(6.79%) and amlodipine(5.24%)，and commonly used traditional Chinese medicines were combined with Shenmai injection(3.64%)，compound Danshen dropping pills(3.40%) and Suxiao Jiuxin pills(3.30%). Conclusion：The CHD patients treated with breviscapine injection are mainly elderly people with complex and diverse comorbidities，and the clinical use of combined drugs needs to be standardized. The combined use of drugs fits with the clinical guidelines of coronary artery disease as well as Chinese medical evidence，and there is a certain pattern to follow，which can provide clues for clinical diagnosis and treatment and optimization of drug use.