Abstract：Objective：To observe the clinical effect of Yiqi Wenyang Huayu tang on chest impediment and heart pain of heart blood stasis obstruction type. Methods：A total of 98 patients with chest impediment and heart pain of heart blood stasis obstruction type were selected and divided into the control group and the observation group according to random number table method， 49 cases in each group. The control group was treated with conventional western medicine， and the observation group was additionally treated with Yiqi Wenyang Huayu tang based on the treatment of the control group. The clinical effect， ECG ST- T changes， vascular endothelial function and hemorheological indexes before and after treatment were compared between the two groups. Results：The total effective rate was 89.80% in the observation group，higher than that of 71.43% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference in ST segment depression value and T wave total inversion value between the two groups(P＞0.05). After treatment，the ST segment depression value and T wave total inversion value in the two groups were lower than those before treatment(P＜0.05)，and the two values in the observation group were lower than those in the control group(P＜0.05). Before treatment， there was no significant difference in the levels of serum endothelin(ET) and nitric oxide(NO) between the two groups(P＞0.05). After treatment， the level of serum ET in the two groups was respectively lower than that before treatment，and the level of serum NO was higher than that before treatment(P＜0.05)；the ET level in the observation group was lower than that in the control group，and the NO level was higher(P＜0.05). Before treatment，there was no significant difference in whole blood high shear viscosity， fibrinogen and hematocrit value between the two groups(P＞0.05). After treatment，the whole blood high shear viscosity，fibrinogen and hematocrit value in the two groups were lower than those before treatment(P＜0.05)， and the above hemorheological indexes in the observation group were lower than those in the control group(P＜0.05). Conclusion： Yiqi Wenyang Huayu tang for chest impediment and heart pain of heart blood stasis obstruction type，can effectively improve the clinical effect，ECG ST-T，vascular endothelial function and hemorheological indexes.