益气温阳化瘀方治疗心血瘀阻型胸痹心痛临床研究
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R541.4

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Clinical Study on Yiqi Wenyang Huayu Tang for Chest Impediment and Heart Pain of Heart Blood Stasis Obstruction Type
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    摘要:

    目的:观察益气温阳化瘀方治疗心血瘀阻型胸痹心痛的临床疗效。方法:选取98 例心血瘀阻型胸痹心痛患者,按随机数字表法分为对照组和观察组各49 例。对照组给予常规西药治疗,观察组在对照组基础上给予益气温阳化瘀方治疗。比较2 组临床疗效及治疗前后心电图ST-T 改变、血管内皮功能及血液流变学指标。结果:观察组总有效率为89.80%,高于对照组71.43%,差异有统计学意义(P<0.05)。治疗前,2 组ST 段压低值及T 波总倒置值比较,差异无统计学意义(P>0.05)。治疗后,2 组ST 段压低值及T 波总倒置值均低于治疗前(P<0.05),且观察组ST 段压低值与T 波总倒置值低于对照组(P<0.05)。治疗前,2 组血清内皮素(ET) 及一氧化氮(NO) 水平比较,差异无统计学意义(P>0.05)。治疗后,2 组血清ET 水平低于治疗前,NO 水平高于治疗前(P<0.05);且观察组ET 水平低于对照组,NO 水平高于对照组(P<0.05)。治疗前,2 组全血高切黏度、纤维蛋白原、红细胞比容比较,差异无统计学意义(P>0.05)。治疗后,2 组全血高切黏度、纤维蛋白原、红细胞比容均低于治疗前(P<0.05),且观察组各血液流变学指标均低于对照组(P<0.05)。结论:益气温阳化瘀方治疗心血瘀阻型胸痹心痛,能有效提高临床疗效,改善心电图ST-T、血管内皮功能及血液流变学指标。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Yiqi Wenyang Huayu tang on chest impediment and heart pain of heart blood stasis obstruction type. Methods:A total of 98 patients with chest impediment and heart pain of heart blood stasis obstruction type were selected and divided into the control group and the observation group according to random number table method, 49 cases in each group. The control group was treated with conventional western medicine, and the observation group was additionally treated with Yiqi Wenyang Huayu tang based on the treatment of the control group. The clinical effect, ECG ST- T changes, vascular endothelial function and hemorheological indexes before and after treatment were compared between the two groups. Results:The total effective rate was 89.80% in the observation group,higher than that of 71.43% in the control group, the difference being significant(P<0.05). Before treatment, there was no significant difference in ST segment depression value and T wave total inversion value between the two groups(P>0.05). After treatment,the ST segment depression value and T wave total inversion value in the two groups were lower than those before treatment(P<0.05),and the two values in the observation group were lower than those in the control group(P<0.05). Before treatment, there was no significant difference in the levels of serum endothelin(ET) and nitric oxide(NO) between the two groups(P>0.05). After treatment, the level of serum ET in the two groups was respectively lower than that before treatment,and the level of serum NO was higher than that before treatment(P<0.05);the ET level in the observation group was lower than that in the control group,and the NO level was higher(P<0.05). Before treatment,there was no significant difference in whole blood high shear viscosity, fibrinogen and hematocrit value between the two groups(P>0.05). After treatment,the whole blood high shear viscosity,fibrinogen and hematocrit value in the two groups were lower than those before treatment(P<0.05), and the above hemorheological indexes in the observation group were lower than those in the control group(P<0.05). Conclusion: Yiqi Wenyang Huayu tang for chest impediment and heart pain of heart blood stasis obstruction type,can effectively improve the clinical effect,ECG ST-T,vascular endothelial function and hemorheological indexes.

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邱婧,陆炜,杨运凤.益气温阳化瘀方治疗心血瘀阻型胸痹心痛临床研究[J].新中医,2021,53(19):65-68

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  • 在线发布日期: 2021-10-09
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